How We Score
How we vet the research — transparency first
How Fasting Triggers a Hidden Hormone to Keep Us Healthy as We Age
This study identifies a hormone pathway that explains how fasting improves health during aging in worms—a finding that could eventually inform human therapies, but needs confirmation in mammals before drawing …
Blood pressure drug losartan rejuvenates aging metabolism in mice and older adults
Losartan, an old blood-pressure drug, shows promise for reversing aging at the molecular level in both animals and early human tests, but we need larger, longer studies measuring real-world health …
How a protein tweak keeps blood-forming stem cells young and extends mouse lifespan
This mouse study shows that tweaking a protein to keep blood-stem cells young also extends lifespan, suggesting stem cell health may be crucial for aging. However, the effect is modest, …
A New NAD+ Supplement Boosts Cells' Energy Without Raising Blood Levels
This early-stage study shows a clever new way to get NAD+ inside cells efficiently, but it's far too preliminary to claim any anti-aging benefit. We're seeing a biomarker shift in …
How Your Body's Own Molecules Fight Aging by Neutralizing Toxic Metabolites
This is promising early-stage research suggesting your body has a natural defense against a form of metabolic damage that drives aging, and common dietary supplements may activate it. However, it's …
How DNA Chaos in Yeast Chromosomes Drives Aging and Life Span Differences
Researchers found a plausible molecular explanation for why genetically identical cells age at different rates, but the work is very early-stage and needs independent peer review and validation before drawing …
Poor neighborhoods linked to faster biological aging in DNA
Living in disadvantaged neighborhoods appears linked to faster biological aging at the DNA level, but this preprint needs peer review and larger studies before we can be confident in the …
How Reduced Phosphatidylcholine Affects Aging and Lifespan in Worms
This early-stage study suggests that how cells build their outer membranes may affect aging, but the findings in worms need to be tested in larger animals and humans before we …
Aging May Be a Spreading Disorder of System-Wide Coordination
This is an intriguing new way to measure aging by tracking how well your body's systems stay coordinated—early results look promising, but the idea is so new it needs independent …
How exercise activates SIRT1, a key aging-control protein
Exercise appears to activate SIRT1, a protein that helps prevent multiple aging processes. This explains some of why exercise extends lifespan, though the research is still young and human studies …
How cells clean up their protein factories as we age
Your cells actively recycle and reshape their protein factories as you age, and this recycling process may be key to healthy aging. When scientists trigger this recycling artificially, it extends …
A plant compound extends lifespan in worms by boosting cellular cleanup and stress defenses
This is solid basic research showing a plant compound can slow aging in worms through multiple cellular mechanisms. However, it's very early-stage work; we don't yet know if it will …
A Protein That Shortens Life: Turning Off pitp-1 Extends Healthspan in Worms
This study identifies a protein (pitp-1) that, when turned off, extends lifespan and improves muscle health in worms by adjusting a well-known aging pathway (mTOR). It's solid basic science that …
Should You Try Fasting for Longevity? What Scientists Currently Know
Fasting might help you lose weight and improve blood sugar control, but we don't yet have solid proof it makes people live longer. Scientists need bigger, longer studies before recommending …
How Genes Control Muscle's Role in Heart and Lung Fitness
This is promising basic research that identifies which genes and regulatory switches control fitness in an animal model, but it's not yet validated in humans and requires peer review and …
A Fruit Fly Gene That Extends Lifespan and Protects Against Stress
This is solid fruit fly research that introduces a smarter way to find aging-related genes, and identifies one promising candidate. However, it's an early-stage finding that needs confirmation in other …
Can a Natural Serum Reverse Skin Aging? Testing Epigenetic Age Across Ethnicities
This is early-stage evidence that a natural ingredient might slow skin aging at the molecular level across all skin types. The results are encouraging but need confirmation with larger, blinded …
A Drug That Kills Aging Cells in Osteoarthritis Without Harming Healthy Ones
This lab study suggests an existing drug (mocetinostat) can kill the problematic aged cells that accumulate in arthritic joints. It's promising early evidence, but much more research—in animals and eventually …
How Aging Breaks Our Immune System—and New Ways to Fix It
This comprehensive review maps out a practical roadmap for repairing age-related immune decline through combination therapies targeting specific broken components—moving aging research from 'why this happens' to 'how we might …
Can a senolytic peptide slow brain aging and memory loss?
This review makes a scientifically plausible case that targeting senescent cells in the brain could slow cognitive aging, but the human evidence is too preliminary to act on. Animal studies …