How We Score
How we vet the research — transparency first
How Caloric Restriction Reshapes Your Metabolism Over 2 Years
This well-designed study provides the first detailed snapshot of metabolic changes during long-term caloric restriction in humans, showing that carbohydrate and fat metabolism shift in time-dependent ways. However, as an …
A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup
Corylin shows genuine promise in a worm model by activating well-established longevity pathways, but these are early-stage findings. Don't expect human supplements or treatments from this work alone—much validation in …
Two-phase aging model reveals critical vulnerability period in flies and mice
This preprint offers an intriguing mathematical framework showing aging may involve a dangerous transition point—but it's early-stage work awaiting peer review and replication. If confirmed, it could refocus aging research …
Plant extract Salvia plebeia triggers cellular cleanup and reverses aging signs in mice
A plant extract activates cellular cleanup (autophagy) and reverses aging markers in mice, with a compound called rosmarinic acid identified as the likely active ingredient—an interesting lead, but human studies …
Can bezisterim slow brain aging in Alzheimer's disease?
An experimental anti-inflammatory drug appears to reverse epigenetic markers of aging in Alzheimer's patients, raising hope for a new longevity-focused therapeutic approach. But this early-stage preprint lacks peer review, has …
Can Young Blood Make You Younger? What Science Actually Shows (and Doesn't)
Young plasma shows real promise in animals, but human clinical evidence is weak and preliminary. The authors warn against treating this as a proven therapy now—rigorous clinical trials are essential …
How caloric restriction keeps blood-forming stem cells young in mice
This mouse study identifies two key genes (KDR and PU.1) that control how caloric restriction rejuvenates blood stem cells, pointing toward potential drug targets. However, human translation remains uncertain, and …
How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks
This computational study maps an intriguing mechanism by which NAD+-mimics could activate SIR2, and identifies a potential drug target—but it's a hypothesis-generating paper, not proof of concept. Experimental validation and …
A Fungal Compound Protects Worm Brains from Amyloid Damage by Boosting Cellular Cleanup
This study shows a fungal compound protects worms from amyloid toxicity through well-known cellular repair mechanisms, which is scientifically interesting. However, it's very early-stage work—many steps and years of research …
How DNA methylation reveals aging in a fish with no genetic variation
This clever study shows that aging leaves a clear chemical signature in DNA methylation—one that emerges independently of genetic variation. While the findings are promising and methodologically sound, they're preliminary …
How Young Blood Rejuvenates Aging Brain Blood Vessels: The IGF-1 Connection
This research identifies a growth factor called IGF-1 as a key player in how young blood rejuvenates aging brains, but suggests it's only part of the story. While promising for …
Why Low-Cholesterol Diets Shorten Lifespan in Female Fruit Flies: A Gut Health Story
In fruit flies, strict low-cholesterol diets backfired—shortening rather than extending life, often by damaging the gut barrier. This doesn't mean cholesterol is healthy in humans, but it suggests that extreme …
Testing a Personalized Digital Health Protocol to Boost Resilience in One Individual
This is an interesting proof-of-concept for using AI and continuous monitoring to track health biomarkers, but it is not evidence that any particular intervention extends human healthspan. It's a self-study …
Broken mitochondria in blood vessel cells trigger a healthy metabolic response in mice
This mouse study reveals that damaging mitochondria in blood vessel linings paradoxically improves metabolism and slows aging through a stress-response mechanism. While scientifically elegant, it's early-stage work that needs independent …
A Plant Compound Delays Aging in Cells by Activating Stress-Defense Pathways
This paper shows a plant compound activates protective cellular pathways in worms and cultured cells, which is interesting mechanistically but a very early stage of research—far from proof that the …
A Blood Test for Midlife Health Can Predict Disease and Improve With Lifestyle Changes
This promising blood test could help middle-aged people understand their disease risk and motivate healthier living, but it's too early to act on. Wait for peer review and replication before …
How metformin extends yeast lifespan through chromatin control and retrotransposon activity
Metformin likely extends yeast lifespan through chromatin changes that activate retrotransposons—previously unknown mechanism worth investigating in mammals. However, this is early-stage yeast research; human relevance remains speculative and requires independent …
Can boosting NAD+ reverse ovarian aging? What we know and don't know yet
NAD+ is plausibly important for ovarian health based on cellular biology, but we're still in the early phase of understanding how it actually works in human ovaries and whether boosting …
Silencing a protein called CG42795 boosts autophagy and extends lifespan in fruit flies
This is early-stage research showing a promising new target (CG42795/TBC1D30) for enhancing cellular autophagy and extending lifespan in model organisms. It's worth following, but it's far too preliminary to guide …
A comprehensive map of how skeletal muscle ages at the genetic level
This is an ambitious genomic atlas that could become a valuable reference for muscle aging research, but it's still a preprint describing correlations and network patterns rather than proven interventions …