How We Score
How we vet the research — transparency first
Rethinking senescent cells: When to stop them, when to keep them
This paper makes a compelling case that we've been thinking about senescent cells too simplistically. Not all aging cells are bad—some actually keep tissues healthy. Future therapies might work better …
Why Aging Cells Sometimes Help—and Sometimes Hurt—Muscle Repair
This paper explains why aging cells are a paradox in muscle repair: briefly helpful during healing, but harmful when they stick around. If this mechanism is correct, drugs that remove …
Rethinking Cellular Aging: Why One-Size-Fits-All Approaches to Senescence Are Failing
This paper doesn't report new discoveries—it's a thoughtful critique arguing that anti-aging researchers have been oversimplifying senescence and should embrace its complexity instead of chasing universal fixes. It's credible as …
Why Blue Zone Residents Live So Long: A Heart Health Perspective
This paper provides a useful framework connecting what makes Blue Zones special to specific cardiovascular mechanisms, but it's a literature summary, not proof. It's a good roadmap for future research, …
How Spermidine and Exercise Work Together to Keep Muscles Young
This paper makes a compelling case that spermidine and exercise activate the cell's cleanup system to preserve muscle, but the evidence is mostly from lab studies and animals—human proof is …
Can metformin protect aging hearts from stress? Early evidence in mice
This mouse study suggests metformin might protect aging hearts from stress damage, but it's too early to know if this will help humans. We need larger, replicated studies and human …
Do taste receptor genes influence weight and lifespan?
This study finds that genetic variants in taste receptors are more common in Sardinian centenarians and linked to body weight, suggesting taste genes may influence longevity—but the evidence is early …
DNA Methylation Clock Predicts Survival in 100-Year-Olds Better Than Brain Tests
A molecular aging clock in blood predicts survival in centenarians better than brain-health tests, suggesting aging happens in multiple ways—but this finding needs independent confirmation before we can trust it.