How We Score
How we vet the research — transparency first
Vitamin K2 May Slow Aging in Worms by Protecting Mitochondria
This is promising early-stage research showing vitamin K2 can activate aging-control pathways in worms, but we need studies in mammals and eventually humans before knowing if it helps people live …
How light therapy reverses sun damage by changing skin cell signaling
This study explains how intense pulsed light—a popular cosmetic treatment—reverses sun damage at the cellular level by blocking collagen-breakdown pathways. While the mechanism makes sense and early data are encouraging, …
How a Traditional Chinese Herb Might Slow Aging Through Immune and Metabolic Pathways
This is credible mechanistic research showing a traditional herb affects aging pathways in yeast and flies, but it's early-stage: independent replication is needed, and there's no evidence it extends human …
Injectable Nicotinamide Riboside Shows Good Safety in Early Human Trials
Injectable nicotinamide riboside appears safe in early testing, but this is only a first small safety check. We need larger studies to know if it actually works or offers real …
Young Blood Plasma Exchange Shows Promise as Safe Treatment for Early Alzheimer's
This study shows that replacing older adults' blood plasma with young donor plasma is safe and can be done in humans—an important first step. But it's far too early to …
How naked mole rats rewired their proteins to live exceptionally long
This study reveals a fascinating clue—naked mole rats have evolved unusual protein structures linked to stress resistance—but it's a preliminary computational analysis that needs experimental follow-up to confirm the story …
A Peanut Compound Reverses Blood Stem Cell Aging in Mice
Researchers found a natural compound from peanuts that restored function to aging blood stem cells in mice—an encouraging lead that requires years of additional testing before potential human use. Don't …
AI Reads Your Heart's Age to Predict Heart Disease Risk
This AI tool shows promise for identifying heart disease risk before symptoms appear, but it's preliminary research that needs peer review and validation before doctors would use it clinically. The …
A Safer Rapamycin-Like Drug Extends Lifespan in Worms
This is early-stage research showing a modified rapamycin might work better than the original drug in simple worms. It's promising but requires years of testing in mammals before anyone should …
Small RNA molecules show promise as aging clocks in blood tests
This editorial makes a reasonable case that scientists should look for better aging biomarkers in blood, but it's a 'think piece' summarizing existing ideas, not proof that these markers work …
How Replacing Damaged Cells and Tissues Could Reverse Aging
This is a roadmap from top aging researchers proposing we move beyond slowing aging to actively repairing and replacing damaged cells and tissues. It's a promising vision backed by real …
How Fasting Triggers a Hidden Hormone to Keep Us Healthy as We Age
This study identifies a hormone pathway that explains how fasting improves health during aging in worms—a finding that could eventually inform human therapies, but needs confirmation in mammals before drawing …
Blood pressure drug losartan rejuvenates aging metabolism in mice and older adults
Losartan, an old blood-pressure drug, shows promise for reversing aging at the molecular level in both animals and early human tests, but we need larger, longer studies measuring real-world health …
How a protein tweak keeps blood-forming stem cells young and extends mouse lifespan
This mouse study shows that tweaking a protein to keep blood-stem cells young also extends lifespan, suggesting stem cell health may be crucial for aging. However, the effect is modest, …
A New NAD+ Supplement Boosts Cells' Energy Without Raising Blood Levels
This early-stage study shows a clever new way to get NAD+ inside cells efficiently, but it's far too preliminary to claim any anti-aging benefit. We're seeing a biomarker shift in …
How Your Body's Own Molecules Fight Aging by Neutralizing Toxic Metabolites
This is promising early-stage research suggesting your body has a natural defense against a form of metabolic damage that drives aging, and common dietary supplements may activate it. However, it's …
How DNA Chaos in Yeast Chromosomes Drives Aging and Life Span Differences
Researchers found a plausible molecular explanation for why genetically identical cells age at different rates, but the work is very early-stage and needs independent peer review and validation before drawing …
Poor neighborhoods linked to faster biological aging in DNA
Living in disadvantaged neighborhoods appears linked to faster biological aging at the DNA level, but this preprint needs peer review and larger studies before we can be confident in the …
How Reduced Phosphatidylcholine Affects Aging and Lifespan in Worms
This early-stage study suggests that how cells build their outer membranes may affect aging, but the findings in worms need to be tested in larger animals and humans before we …
Aging May Be a Spreading Disorder of System-Wide Coordination
This is an intriguing new way to measure aging by tracking how well your body's systems stay coordinated—early results look promising, but the idea is so new it needs independent …