How We Score
How we vet the research — transparency first
Can a longevity protein protect Parkinson's patients from memory loss?
A longevity protein shows promise in helping Parkinson's patients preserve cognitive function through mouse and genetic studies, but these findings need to be confirmed in human clinical trials before we …
Which biological aging markers best predict health decline? A 7-year study of 1,083 older adults
This well-conducted study compared 16 aging biomarkers and identified two (Allostatic Load and DunedinPACE) as the most reliable predictors of health decline in older age, but the findings are recent …
What makes centenarians tick? A metabolic fingerprint of extreme longevity
This is solid observational research identifying intriguing metabolic differences in centenarians that merit follow-up investigation. However, because it's not yet replicated and cannot prove cause-and-effect, treat the findings as promising …
Dogs as aging models: A new study validates canine biomarkers of aging
This is a promising early-stage study that could eventually validate dogs as a faster, more practical aging research model—but the critical results on predicting health outcomes are still being analyzed …
A New Blood Test that Predicts Aging and Disease Risk Across Millions of People
This is rigorous work that validates a promising new way to measure biological age using standard blood tests across a large, diverse population. However, it's too early to use this …
Your retinal images may reveal hidden aging and heart-kidney-metabolic disease risk
This is a well-executed observational study showing that an AI-analyzed eye photograph correlates with cardiovascular and metabolic disease risk, but it's not yet proof that this screening tool will help …
Gene activity patterns reveal how some people stay healthy longer
This paper identifies gene-expression patterns associated with healthy aging in long-lived families and develops a clock that predicts mortality risk. It's promising foundational work, but we need independent replication and …
Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels
This is a rigorous mechanistic study identifying a promising vascular target (TNAP) that could allow us to chemically mimic exercise's memory-boosting effects. However, it's currently mice-only science; human safety and …
How pregnancy ages some body systems while rejuvenating others—insights for slowing aging
Pregnancy provides a natural 'stress test' showing that some body systems can rejuvenate while others age—findings that challenge our assumptions about irreversible aging and could inspire new research directions, though …
Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity
A Nature-published study provides good evidence that vigorous exercise delivers greater health benefits per minute than lighter activity, but this Reddit summary overstates certainty by presenting dramatic risk reduction ratios …
Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds
Spermidine in foods like beans and mushrooms shows a strong association with living longer, but this could mean either spermidine itself is beneficial or it's simply a marker of eating …
Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction
Scientists found that aging damages lysosomes—cellular garbage disposals—in blood-forming stem cells, and blocking the enzyme that causes this damage restored youthful function in mouse cells. This is a promising mechanistic …
Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure
Dr. Conboy presents credible scientific criticism of epigenetic aging clocks, arguing they measure statistical patterns rather than true biological age and miss key aging hallmarks—viewers should understand this as expert …
NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science
While early animal research made NAD-boosting supplements seem promising, rigorous follow-up studies show they don't extend lifespan in mice or improve symptoms in humans, even when they successfully raise NAD …