How We Score
How we vet the research — transparency first
Castration & Lifespan: What the Science Actually Shows About Testosterone
While castration does extend lifespan in animals and historical eunuchs, the real lesson isn't 'lower your testosterone'—it's that excessive growth signaling may drive aging, and that healthy testosterone levels remain …
Exercise, Heat, and Cold: Dr. Patrick's Healthspan Optimization Guide
This is a well-credentialed scientist presenting solid evidence that vigorous exercise is one of the most powerful life-extending interventions available; the core claims align with peer-reviewed science, though some study …
Seed Oils vs. Lard: What the Science Actually Shows
Both seed oils and lard are bad when used for frying because fried foods are calorie-dense junk; the choice between them matters far less than avoiding regular consumption. Don't fall …
r/longevity Introductory Guide: Resources for Aging Biology Research
This is a well-curated introductory resource for understanding legitimate aging biology research, appropriately warning against quackery while directing readers to peer-reviewed papers and academic institutions. It's an excellent starting point …
Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause
This is a credible, well-informed conversation about detecting Alzheimer's disease before symptoms appear—an important topic for brain health. However, viewers should note that specific studies and evidence aren't cited in …
Women's Alzheimer's Prevention: Lifestyle, Menopause, and Emerging Treatments
This is a credible, measured discussion by an Alzheimer's researcher emphasizing that consistent lifestyle habits (exercise, sleep, nutrition, stress management) are the proven foundation of dementia prevention for women, with …
Beta-2-Microglobulin and Neurogenesis: What's My Data?
Beta-2-microglobulin shows promise as a biomarker linked to brain health and aging, with solid mouse studies and intriguing human associations, but human causality remains unproven. Lustgarten's personal tracking is methodologically …
NAD+ Biology and Aging: Expert Insights on Boosting NAD Levels
NAD is genuinely important for cellular function, but the popular claim that "NAD declines with age" in healthy people is overstated—disease and metabolic problems are more reliable drivers of NAD …
What Blood Biomarkers Predict Living to 100? Insights from Swedish Centenarian Study
A high-quality Swedish study found that certain blood biomarker patterns in middle age—including higher cholesterol and iron, lower blood sugar and kidney markers—were associated with living to 100, but this …
How healthy diets add years to your life—even if your genes say otherwise
Multiple healthy dietary patterns—Mediterranean, plant-based, DASH, and others—consistently added 1.5–3 years of life expectancy in a large study, and these benefits occurred regardless of whether people carried genetic variants linked …
Nine Core Mechanisms Explain Why We Age
This paper is a 'greatest hits' summary that organized everything we knew about aging into nine common patterns. It didn't discover new biology, but it gave researchers a shared roadmap—think …
How Adjuvanted Vaccines Help Older Adults Build Better Immune Memory
This study reveals that adjuvanted vaccines work in older adults by activating a different immune pathway (TH17 cells) rather than the traditional one that weakens with age. While promising for …
How Air Pollution Slows Recovery from Physical Disability in Older Adults
Air pollution appears to increase the risk of developing mobility problems in older adults and slows recovery from disability—a concerning public health finding that suggests improving air quality could be …
Brain regions for effort trade-offs: where the mind weighs reward against difficulty
This preprint identifies how the brain's decision-making hub (anterior cingulate cortex) separates the 'reward signal' from the 'difficulty signal,' then combines them to decide if effort is worth it. While …
People with schizophrenia show signs of accelerated aging across brain and body
This is credible, well-replicated evidence that people with schizophrenia show signs of faster biological aging—though we don't yet know why. The finding is significant enough to motivate research into anti-aging …
Brain networks underlying impulsive financial choices may help diagnose mental health conditions
This is solid methodological research that tells neuroscientists how to reliably study brain circuits involved in impulsive choices, but it doesn't directly reveal new aging biology or interventions. It's a …
How a kidney protein drives aging after injury—and why blocking it could help
This is solid preclinical work showing that a kidney protein called TIMP2 actively drives the transition from acute to chronic kidney disease in mice by promoting cellular aging and scarring. …
How Gum Disease Ages Your Body: A Link to Earlier Death
Gum disease appears linked to earlier death, and accelerated aging (measured by blood biomarkers) may explain part of this risk—but other biological pathways likely matter more. This is promising preliminary …
A Lifetime of Learning May Protect Against Alzheimer's Disease
People who have engaged in learning and mentally stimulating activities throughout their lives show lower Alzheimer's risk and maintain better cognitive function, even if brain pathology is present—suggesting lifelong mental …
Blood Proteins of Centenarians Reveal Secrets of Extreme Longevity
This is solid discovery research that maps real molecular differences in centenarians with decent cross-study validation, but it identifies associations, not proven mechanisms. The findings are promising enough to guide …