How We Score
How we vet the research — transparency first
Childhood Trauma's Long Shadow: Brain Changes Persist into Aging
This well-designed study provides solid evidence that childhood adversity correlates with both lasting mental health problems and measurable brain volume reductions in mid-to-late adulthood, but because it's a snapshot rather …
Can we measure physical resilience in older adults? Testing three different approaches
Current methods for measuring physical resilience in older adults don't agree with each other and don't reliably predict who will decline or die. This suggests we need to rethink how …
Sleep Apnea and Mental Health: A Large Canadian Study Shows Strong Links in Aging
This large, well-conducted Canadian study found that people at high risk of sleep apnea are significantly more likely to experience depression, anxiety, or other mental health problems both now and …
How plants age: DNA methylation decay as a molecular clock of aging
This elegant plant study suggests that epigenetic aging (DNA methylation decay) may be a side effect rather than a driver of aging—a finding that could reshape how we interpret epigenetic …
Building a 10,000-person aging study in Northern Italy: methods and early findings
This describes an important research infrastructure being built to study aging in Southern Europe, with promising early signs that the detailed measurement approach works. Don't expect definitive answers yet—real insights …
Blood Pressure Changes May Signal Cognitive and Functional Decline in the Very Elderly
This study suggests that unexpected changes in blood pressure in people aged 85+ may warn of upcoming cognitive or functional decline, but the finding is preliminary and based on a …
How the brain's energy pathways change across regions and lifespan
This paper creates detailed maps of how the brain's energy-producing systems are organized and how they change from birth through adulthood—valuable context for understanding brain aging, but not yet evidence …
Mitochondrial Transplantation Restores Muscle Function
Promising results but more studies needed.
Telomere Extension via AAV Gene Therapy in Primates
Promising results but more studies needed.
Epigenetic Clock Reversal Achieved with Lifestyle Intervention
Promising results but more studies needed.