Researchers tested 287 Japanese adults to see which of 52 lifestyle factors (diet, exercise, sleep, stress habits) correlated with six different epigenetic aging clocks. They found that smoking, high-intensity exercise, and sauna use showed the …
Researchers used mass spectrometry to measure 2,295 people's metabolites (small molecules in blood) and built a 'metabolomic clock' that accurately predicts chronological age and tracks biological aging. People whose metabolomic age exceeded their actual age …
This paper proposes that tongue pressure—how forcefully someone can press their tongue against the roof of their mouth—may be a useful marker of overall frailty and longevity in older people. The authors argue measuring tongue …
Researchers compared nail structure and zinc content in 64 older adults with and without visible nail changes, finding no significant difference in zinc levels between the two groups. The study suggests nail aging is more …
This review examines new tools called single-cell aging clocks that measure biological age in individual cells rather than averaging across thousands of cells at once. These tools reveal that aging varies dramatically between cell types …
This commentary questions whether JST-IC trajectory patterns genuinely reflect aging decline or instead capture stable life-course abilities shaped by education, technology familiarity, and generational factors. The authors argue researchers need to reconsider how to interpret …
Researchers found that kidney damage from aging and hypertension is associated with accumulation of senescent (aging) cells in the glomeruli—the kidney's filtering units. The study identifies specific molecular markers of cellular senescence that correlate with …
In adults aged 85+, researchers used advanced pattern-matching analysis to find that drops in blood pressure preceded cognitive decline, while rises in blood pressure preceded difficulty with daily activities. This suggests BP changes in very …
This is a protocol paper announcing a planned scoping review that will search the scientific literature for evidence connecting oral microbiome composition to three common aging syndromes: frailty, muscle loss, and cognitive disorders in people …
Researchers in Italy are establishing a large longitudinal cohort study to track how people age, combining detailed health assessments with genetic and protein measurements. Early results show the approach works and reveal links between frailty …
Researchers validated a quick executive function test (TCST) that can reliably distinguish normal aging from Alzheimer's disease with 84% accuracy. The study provides age-adjusted scoring norms that make the test more clinically useful for early …
This essay identifies critical gaps in our understanding of why males and females show different rates of age-related diseases, infections, and vaccine responses—differences driven by sex hormones and genetics. The authors outline priority research areas …
This study found that older adults show increased 'neural noise' (flatter EEG patterns) compared to younger adults during working memory tasks, and this noise correlates with less efficient brain processing. The findings suggest aging brains …
Researchers found that the health of a small brain region called the locus coeruleus is linked to deep sleep loss in aging and Alzheimer's disease, with stronger effects in women. The study suggests that protecting …
Researchers analyzed blood proteins from Swiss centenarians and discovered 37 proteins associated with a 'younger' profile that may explain why some people live to 100 and stay healthy. By comparing centenarian patterns across two independent …