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Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Reversing liver scarring with reprogramming mRNA in mice

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state.

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state. This proof-of-concept study suggests mRNA-based cellular rejuvenation …

Journal of controlled release : official journal of the Controlled Release Society Feb 15, 2026

41 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

DMTF1 Gene May Reverse Brain Aging in Neural Stem Cells

Researchers identified DMTF1, a transcription factor, as potentially therapeutic for reversing age-related decline in neural stem cell proliferation caused by telomere shortening. The mechanism involves DMTF1 regulating SWI/SNF chromatin complexes to activate E2F genes, a …

r/longevity Feb 15, 2026

36 Early

Disputed Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

Genetics May Account for 50% of Lifespan, New Study Suggests

A 2026 study by Shenhar and Alon claims genetics determine 50–55% of human lifespan—roughly double previous estimates of 15–30%—by filtering out accidental deaths from twin data. The finding suggests aging is a genetically regulated process …

r/Biohackers Feb 15, 2026

16 Weak

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Rewinding the Brain's Age: Gene Therapy Restores Memory in Aging Mice

Researchers used a gene therapy technique to partially "reprogram" neurons that store memories in aged mice and Alzheimer's disease models, reversing signs of aging in those cells and restoring learning and memory to young-animal levels. …

Neuron Feb 13, 2026

45 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

How Partial Reprogramming Reverses Aging Marks on Key Genes

Researchers found that partial cellular reprogramming in aging mice reverses age-related chemical changes (DNA methylation patterns) specifically on genes controlled by a protein complex called PRC2. This suggests PRC2 may be a central hub controlling …

Molecular systems biology Feb 13, 2026

40 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Five genes linked to cellular aging may drive rheumatoid arthritis risk

Using genetic data from large population studies, researchers identified five genes involved in cellular senescence (aging) that appear to causally influence rheumatoid arthritis risk, with BCL2L1 and RAF1 showing the strongest associations. This computational study …

Medicine Feb 12, 2026

46 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Boosting Brain Protein Maintenance by Enhancing an Enzyme Linked to Neurodegeneration

This concept paper proposes a new approach to treating Alzheimer's, Parkinson's, and ALS by directly increasing production of OGT—an enzyme that regulates thousands of proteins—rather than using existing indirect methods. The authors suggest using antisense …

Chembiochem : a European journal of chemical biology Feb 12, 2026

30 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Understanding FOXO proteins: Key to unlocking longevity mechanisms

This review examines FOXO transcription factors—evolutionary conserved proteins linked to lifespan extension in animals and associated with human longevity via genetic studies. The authors argue that FOXO's role in cellular resilience against stress explains its …

The Biochemical journal Feb 12, 2026

33 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Can you breed bugs for more babies without losing lifespan? A surprising answer from predatory insects

Researchers bred a predatory bug (Orius albidipennis) to produce 76% more eggs than normal without observing the typical trade-off where high reproduction shortens lifespan or reduces hunting ability. This finding challenges evolutionary theory and could …

Environmental entomology Feb 12, 2026

38 Early

Promising Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

How plants age: DNA methylation decay as a molecular clock of aging

Researchers found that aging plants lose epigenetic control—specifically, DNA methylation patterns decay over time, allowing normally silenced genes to turn on. Remarkably, they identified a genetic program that can be manipulated to prevent this decay …

Science (New York, N.Y.) Feb 12, 2026

57 Promising

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Why Fanconi Anaemia Reveals How DNA Damage Speeds Up Aging

Fanconi anaemia, a rare genetic disorder of DNA repair, compresses multiple hallmarks of aging into childhood—offering scientists a natural 'fast-forward' model to study how genome damage, immune dysfunction, and epigenetic changes drive aging and cancer. …

Ageing research reviews Feb 12, 2026

33 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

How Oxytocin Decline Accelerates Aging—and Why It Might Be Reversible

This commentary argues that oxytocin, a hormone that decreases with age, may be a master regulator of aging through epigenetic changes, mitochondrial damage, and inflammation—and that nasal oxytocin administration could reverse these effects. The claims …

Aging cell Feb 12, 2026

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Two neurodegenerative diseases share 13 genetic pathways: a key to understanding neurodegeneration

Researchers identified 13 genes that are mutated in both amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease (CMT)—two otherwise distinct neurological disorders. This suggests that despite their clinical differences, these diseases may operate through overlapping molecular …

Amino acids Feb 12, 2026

32 Early

Promising Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Telomere Extension via AAV Gene Therapy in Primates

Single injection of telomerase gene therapy extended telomeres by 20% in macaques.

Cell Feb 12, 2026 n=24

62 Promising