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Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How to Reverse Age-Related Immune System Decline

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer.

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors survey promising rejuvenation strategies—from …

Science advances Feb 15, 2026

40 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Longevity and Innovation: Cardiac Resynchronization Therapy in a 100-Year-Old Patient With Severe Heart Failure-A 4-Year Follow-Up.

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony.

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. This case report presents a 100-year-old male with a history of atrial fibrillation …

Case reports in cardiology Feb 15, 2026

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Natural Products Targeting the PI3K/Akt/mTOR-Mediated Autophagy Pathway in Cancer Therapy: Recent Advances and Clinical Perspectives.

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer.

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Natural products offer a …

Journal of natural products Feb 15, 2026

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Inflammatory milieu and role of epigenetic modifications in high-grade serous ovarian cancer.

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance.

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. The disease progression is largely influenced by a dynamic tumor microenvironment (TME), …

Clinical epigenetics Feb 15, 2026

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Orthodontic treatment positively influences behavior and perception on age recognition.

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age.

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. MATERIALS AND METHODS: Adult laypeople (N = 80; 19-84 years) were asked to "estimate the age" and "select the younger …

The Angle orthodontist Feb 15, 2026

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Revision Neck Lift Surgery: A Systematic Review of Indications, Techniques, and Outcomes.

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures.

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures. Evidence remains sparse and heterogeneous. …

Aesthetic plastic surgery Feb 15, 2026

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Predictors of Readiness to Engage in Advance Care Planning Among Older Adults With Serious Illness: Baseline Findings From the EQUAL ACP Study.

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care.

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. However, disparities in ACP engagement persist, particularly among African American older adults. This study examined …

Journal of the American Geriatrics Society Feb 15, 2026

44 Early

Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary YouTube

NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science

Dr.

Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …

Dr Brad Stanfield Feb 15, 2026

67 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How vaccines strengthen immunity and promote healthy aging

This review argues that strategic vaccination in older adults can combat age-related immune decline (immunosenescence) and reduce serious infections, hospitalizations, and death. The authors propose 'immunofitness' as a practical goal of healthy aging, supported by …

Human vaccines & immunotherapeutics Feb 12, 2026

30 Early

Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Observational PubMed

How Adjuvanted Vaccines Help Older Adults Build Better Immune Memory

Researchers discovered that when older adults receive a vaccine with an immune-boosting adjuvant, their bodies generate a specific type of immune cell (TH17) that compensates for age-related weakening of other immune defenses. This finding explains …

Science advances Feb 12, 2026

50 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How Hormonal Imbalances Drive the Combination of Obesity and Muscle Loss

This review examines how age-related declines in hormones like testosterone, growth hormone, and thyroid function create a perfect storm for simultaneous fat gain and muscle loss—a condition called sarcopenic obesity. The authors argue that understanding …

Annals of medicine Feb 12, 2026

35 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Case-Control PubMed

Brain glutamate elevation in hospitalized older adults with delirium

This small study found that hospitalized older people experiencing delirium had higher glutamate levels in their brain tissue compared to those without delirium, suggesting a potential toxic process that could explain cognitive decline after delirium. …

Age and ageing Feb 12, 2026

44 Early

Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Cohort Study PubMed

Can we measure physical resilience in older adults? Testing three different approaches

Researchers compared three methods for measuring how well older adults bounce back from illness or injury, testing them in two groups: cancer patients undergoing chemotherapy and emergency department patients. They found that the different methods …

Age and ageing Feb 12, 2026

54 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Case-Control PubMed

Stem Cell Transplants Show Promise for Morquio A Syndrome in Children

A study of 41 children with Morquio A, a rare genetic disorder affecting bone and organ development, found that allogeneic hematopoietic cell transplantation (essentially replacing diseased blood-forming cells with healthy donor cells) was safe and …

Transplantation and cellular therapy Feb 12, 2026

44 Early