Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training

Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. In studies, lowering this protein in mice dramatica

Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. In studies, lowering this protein in mice dramatically improved their exercise …

medrxiv (preprint) Feb 15, 2026

25 Early

Design 7

Sample 5

Peer Review 3

Replication 4

Transparency 6

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-prote

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal …

Journal of agricultural and food chemistry Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Why Women Develop Alzheimer's Earlier: Brain Changes Begin in Midlife

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences alone. Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male pr

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences …

Peter Attia Feb 15, 2026

48 Early

Design 13

Sample 7

Peer Review 8

Replication 9

Transparency 11

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. The discussion covers the emerging ability to detect precli

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. The discussion covers the emerging ability to detect preclinical Alzheimer's disease through biomarkers and imaging before …

Peter Attia Feb 15, 2026

50 Promising

Design 12

Sample 8

Peer Review 8

Replication 11

Transparency 11

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure

Dr. Dr. Irina Conboy, a leading aging researcher at UC Berkeley, critiques the current methodology and biological validity of epigenetic aging clocks, arguing they optimize for statistical prediction rath

Dr. Irina Conboy, a leading aging researcher at UC Berkeley, critiques the current methodology and biological validity of epigenetic aging clocks, arguing they optimize for statistical prediction rather than biological relevance and fail to detect …

Lifespan.io Feb 15, 2026

66 Promising

Design 15

Sample 13

Peer Review 12

Replication 13

Transparency 13

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

TMAO: Health Risks, Dietary Sources, and Personalized Tracking

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The presenter analyzes 21 personal biomarker tests to …

Mike Lustgarten Feb 15, 2026

36 Early

Design 8

Sample 6

Peer Review 7

Replication 7

Transparency 8

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Self-Tracked Diet & Biological Age: One Man's 15-Year Younger Result

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specifi

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specific dietary experiments targeting DHEA-sulfate improvement …

Mike Lustgarten Feb 15, 2026

29 Early

Design 5

Sample 4

Peer Review 6

Replication 3

Transparency 11

How we score →

Disputed Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomark

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. While he achieved a 48 µM NAD+ level (considered 'optimal' by his …

Mike Lustgarten Feb 15, 2026

24 Weak

Design 3

Sample 2

Peer Review 5

Replication 2

Transparency 12

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rath

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. He demonstrates a self-tracking …

Mike Lustgarten Feb 15, 2026

41 Early

Design 8

Sample 9

Peer Review 7

Replication 7

Transparency 10

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Beta-2-Microglobulin and Neurogenesis: What's My Data?

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains. Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains. He presents his …

Mike Lustgarten Feb 15, 2026

51 Promising

Design 11

Sample 9

Peer Review 11

Replication 8

Transparency 12

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Oral Microbiome's Link to Alzheimer's Disease: New Research

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise. Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cyt

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise. The oral cavity, being closer to …

Mike Lustgarten Feb 15, 2026

43 Early

Design 11

Sample 6

Peer Review 11

Replication 7

Transparency 8

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

Horvath's Epigenetic Clocks: Measuring and Reversing Aging

Steve Horvath pioneered DNA methylation-based biological age clocks that quantify aging at the cellular level, with GrimAge being his most advanced mortality predictor. His work represents a major breakthrough in aging measurement and has attracted …

r/longevity Feb 15, 2026

30 Early

Design 6

Sample 5

Peer Review 7

Replication 7

Transparency 5

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

What Blood Biomarkers Predict Living to 100? Insights from Swedish Centenarian Study

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme markers. A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme …

r/ScientificNutrition Feb 15, 2026

60 Promising

Design 14

Sample 13

Peer Review 12

Replication 11

Transparency 10

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

Four blood proteins linked to longevity and healthy aging across generations

Researchers identified four plasma proteins—GSN, F2, CRTAC1, and HP—that predict who will stay healthy and live longer, by analyzing blood samples from elderly Dutch siblings and their middle-aged children over up to 22 years. These …

medrxiv (preprint) Feb 13, 2026

40 Early

Design 11

Sample 13

Peer Review 3

Replication 5

Transparency 8

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

Blood Protein Signatures of Cell Aging Predict Health and Disease Risk

Researchers identified protein signatures in blood that reflect aging in 14 different cell types, and found these markers predict disease onset and health status better than general aging markers. In two large longitudinal studies, immune …

medrxiv (preprint) Feb 13, 2026

39 Early

Design 11

Sample 13

Peer Review 3

Replication 5

Transparency 7

How we score →