Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Why Women Develop Alzheimer's Earlier: Brain Changes Begin in Midlife

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences alone.

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences …

Peter Attia Feb 15, 2026
48 Early
Design 13
Sample 7
Peer Review 8
Replication 9
Transparency 11
How we score →
Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health.

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. The discussion covers the emerging ability to detect preclinical Alzheimer's disease through biomarkers and imaging before …

Peter Attia Feb 15, 2026
50 Promising
Design 12
Sample 8
Peer Review 8
Replication 11
Transparency 11
How we score →
Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure

Dr.

Dr. Irina Conboy, a leading aging researcher at UC Berkeley, critiques the current methodology and biological validity of epigenetic aging clocks, arguing they optimize for statistical prediction rather than biological relevance and fail to detect …

Lifespan.io Feb 15, 2026
66 Promising
Design 15
Sample 13
Peer Review 12
Replication 13
Transparency 13
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

TMAO: Health Risks, Dietary Sources, and Personalized Tracking

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone.

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The presenter analyzes 21 personal biomarker tests to …

Mike Lustgarten Feb 15, 2026
36 Early
Design 8
Sample 6
Peer Review 7
Replication 7
Transparency 8
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Self-Tracked Diet & Biological Age: One Man's 15-Year Younger Result

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock.

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specific dietary experiments targeting DHEA-sulfate improvement …

Mike Lustgarten Feb 15, 2026
29 Early
Design 5
Sample 4
Peer Review 6
Replication 3
Transparency 11
How we score →
Disputed Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers.

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. While he achieved a 48 µM NAD+ level (considered 'optimal' by his …

Mike Lustgarten Feb 15, 2026
24 Weak
Design 3
Sample 2
Peer Review 5
Replication 2
Transparency 12
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges.

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. He demonstrates a self-tracking …

Mike Lustgarten Feb 15, 2026
41 Early
Design 8
Sample 9
Peer Review 7
Replication 7
Transparency 10
How we score →
Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Beta-2-Microglobulin and Neurogenesis: What's My Data?

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains.

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains. He presents his …

Mike Lustgarten Feb 15, 2026
51 Promising
Design 11
Sample 9
Peer Review 11
Replication 8
Transparency 12
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Oral Microbiome's Link to Alzheimer's Disease: New Research

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise.

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise. The oral cavity, being closer to …

Mike Lustgarten Feb 15, 2026
43 Early
Design 11
Sample 6
Peer Review 11
Replication 7
Transparency 8
How we score →