This review examines how CXC chemokines—signaling proteins released by aging cells—contribute to age-related diseases and cancer. The authors propose these molecules could become biomarkers for aging and targets for new longevity therapies, though most evidence …
This review highlights how T cells in the brain show signs of exhaustion as we age, and describes a promising engineered immune protein that could restore brain immune function by rebalancing inflammatory signals. The work …
Researchers discovered that IL-2 signaling in B cells activates a regulatory program that produces anti-inflammatory IL-10, especially in aging B cells. In a mouse model of multiple sclerosis, this pathway was protective—loss of IL-2 signaling …
Researchers mapped five key energy-producing pathways across the human brain using genetic data, finding they're distributed differently in sensory areas and follow distinct aging patterns—peaking in childhood for energy production, but declining throughout life for …
Researchers developed engineered immune-targeting proteins to reduce brain inflammation and boost neurogenesis in aged mice, resulting in improved cognitive performance. The approach demonstrates that modulating immune dysfunction—a hallmark of aging—may be a viable strategy to …
Researchers studied how GABA receptors—which normally act as brakes on brain activity—change in mice genetically engineered to develop amyloid pathology similar to Alzheimer's disease. They found that these receptors are altered by the disease itself, …
Transplanting young muscle stem cells into aged mice improved motor function and reduced anxiety through secreted proteins that promote blood vessel growth and immune regulation. The benefits persisted for up to 2 months, suggesting these …
This is a materials science paper about battery electrode design, not longevity research. It describes a method to improve tin anode performance in aqueous batteries by controlling ion nucleation patterns. While innovative for battery technology, …
A small clinical trial found that extracellular vesicles from a patient's own blood can treat temporomandibular joint osteoarthritis by selectively eliminating senescent (aged) chondrocytes and promoting bone regeneration. The therapy worked better than hyaluronic acid …
Researchers found that WTAP, a protein involved in gene regulation, is overactive in periodontitis and causes stem cells in the tooth-supporting tissue to age prematurely and lose their ability to form bone. Blocking WTAP reversed …
This review argues that senescent cells—aging cells stuck in a non-dividing state—can actually promote cancer growth and drug resistance, and that new drugs called senotherapeutics could selectively kill these problematic cells alongside standard cancer treatments. …
This review examines follistatin-like protein 1 (FSTL1), a secreted protein that regulates inflammation, cellular aging, and tumor growth through multiple signaling pathways. The authors propose FSTL1 as a promising therapeutic target for age-related diseases like …
Researchers found that liraglutide, a GLP-1 drug used for diabetes, improved mitochondrial function and reduced oxidative stress in aging heart cells made insulin-resistant in the lab. The effect required a protein called casein kinase 2 …
Researchers found that B cells (immune cells) drive the aging of CD4 T cells, a key component of adaptive immunity, and that removing B cells extended both healthspan and lifespan in mice. The effect appears …
Researchers found that eugenol, a natural compound from cloves, can reduce premature aging in blood vessel cells by suppressing a protein called MFG-E8. The effect was demonstrated in both cell cultures and aged mice, suggesting …