Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

DMTF1 Gene May Reverse Brain Aging in Neural Stem Cells

Researchers identified DMTF1, a transcription factor, as potentially therapeutic for reversing age-related decline in neural stem cell proliferation caused by telomere shortening. The mechanism involves DMTF1 regulating SWI/SNF chromatin complexes to activate E2F genes, a …

r/longevity Feb 15, 2026
36 Early
Design 12
Sample 6
Peer Review 5
Replication 7
Transparency 6
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Disputed Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

Genetics May Account for 50% of Lifespan, New Study Suggests

A 2026 study by Shenhar and Alon claims genetics determine 50–55% of human lifespan—roughly double previous estimates of 15–30%—by filtering out accidental deaths from twin data. The finding suggests aging is a genetically regulated process …

r/Biohackers Feb 15, 2026
16 Weak
Design 3
Sample 2
Peer Review 3
Replication 4
Transparency 4
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