Disputed Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary Reddit

NAD Precursors: What Science Says About NR vs NMN Supplements

This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is exercise recovery. This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is ex

This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is exercise …

r/Biohackers Feb 16, 2026

23 Weak

Design 4

Sample 3

Peer Review 5

Replication 5

Transparency 6

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

Urolithin A and cardiovascular health: preclinical promise meets human biomarker data

A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy older adults. A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy olde

A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy older adults. The discussion covers mechanism, bioavailability challenges, and …

r/Biohackers Feb 16, 2026

44 Early

Design 11

Sample 7

Peer Review 9

Replication 8

Transparency 9

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Randomised Controlled Trial Reddit

Can Polyphenol-Rich Foods Slow Epigenetic Aging?

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc. A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure o

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …

Aging Feb 15, 2026

47 Early

Design 12

Sample 6

Peer Review 13

Replication 7

Transparency 9

How we score →

Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction

Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Blocking a key enzyme (v-ATPase) with an inhibi

Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Blocking a key enzyme (v-ATPase) with an inhibitor restored youthful function and dramatically improved …

r/longevity Feb 15, 2026

60 Promising

Design 13

Sample 12

Peer Review 11

Replication 12

Transparency 12

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5. A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges impo

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …

r/Biohackers Feb 15, 2026

53 Promising

Design 9

Sample 10

Peer Review 12

Replication 9

Transparency 13

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to modera

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. The post claims just 9 minutes …

r/Biohackers Feb 15, 2026

50 Promising

Design 11

Sample 13

Peer Review 12

Replication 8

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

How Exercise Clears Damaged Cells and Reverses Muscle Aging

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity.

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. The post frames exercise as a cellular-level …

r/Nootropics Feb 15, 2026

32 Early

Design 9

Sample 4

Peer Review 8

Replication 5

Transparency 6

How we score →

Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

r/longevity Introductory Guide: Resources for Aging Biology Research

This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university labs studying the biology of aging. This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university la

This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university labs studying the biology of aging. The post establishes the …

r/longevity Feb 15, 2026

64 Promising

Design 13

Sample 12

Peer Review 14

Replication 13

Transparency 12

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

Horvath's Epigenetic Clocks: Measuring and Reversing Aging

Steve Horvath pioneered DNA methylation-based biological age clocks that quantify aging at the cellular level, with GrimAge being his most advanced mortality predictor. His work represents a major breakthrough in aging measurement and has attracted …

r/longevity Feb 15, 2026

30 Early

Design 6

Sample 5

Peer Review 7

Replication 7

Transparency 5

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

DMTF1 Gene May Reverse Brain Aging in Neural Stem Cells

Researchers identified DMTF1, a transcription factor, as potentially therapeutic for reversing age-related decline in neural stem cell proliferation caused by telomere shortening. The mechanism involves DMTF1 regulating SWI/SNF chromatin complexes to activate E2F genes, a …

r/longevity Feb 15, 2026

36 Early

Design 12

Sample 6

Peer Review 5

Replication 7

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Life Expectancy Gains Are Slowing—Here's Why

A PNAS study shows that life expectancy improvements in high-income countries have decelerated 37-52% for cohorts born 1939-2000, primarily because infant mortality is now near zero, eliminating the easy statistical gains of the 20th century. …

r/longevity Feb 15, 2026

34 Early

Design 8

Sample 6

Peer Review 7

Replication 7

Transparency 6

How we score →

Disputed Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

Genetics May Account for 50% of Lifespan, New Study Suggests

A 2026 study by Shenhar and Alon claims genetics determine 50–55% of human lifespan—roughly double previous estimates of 15–30%—by filtering out accidental deaths from twin data. The finding suggests aging is a genetically regulated process …

r/Biohackers Feb 15, 2026

16 Weak

Design 3

Sample 2

Peer Review 3

Replication 4

Transparency 4

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

1,500 Days Sober: Biomarkers Show Dramatic Health Recovery After Alcoholism

A 34-year-old documents remarkable biomarker improvements (biological age 23. A 34-year-old documents remarkable biomarker improvements (biological age 23.7, normalized liver function, excellent metabolic markers) after 1,500 days of sobriety combined with consistent lifestyle

A 34-year-old documents remarkable biomarker improvements (biological age 23.7, normalized liver function, excellent metabolic markers) after 1,500 days of sobriety combined with consistent lifestyle practices. The author emphasizes that fundamentals like alcohol elimination, cardio, sleep, …

r/Biohackers Feb 15, 2026

28 Early

Design 3

Sample 2

Peer Review 4

Replication 5

Transparency 14

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

What Blood Biomarkers Predict Living to 100? Insights from Swedish Centenarian Study

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme markers. A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme …

r/ScientificNutrition Feb 15, 2026

60 Promising

Design 14

Sample 13

Peer Review 12

Replication 11

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary Reddit

High-Dose Creatine for Brain Function: 2024 Study Breakdown and Dosing Insights

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24. A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.5% during sleep deprivation, with vegetarians showing 2x greater benefits th

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.5% during sleep deprivation, with vegetarians showing 2x greater benefits than meat-eaters. The post argues current 5g/day recommendations are …

r/Nootropics Feb 15, 2026

37 Early

Design 8

Sample 5

Peer Review 8

Replication 7

Transparency 9

How we score →