Preliminary Lifestyle — Diet, exercise, and behavioral interventions Randomised Controlled Trial Reddit

Can Polyphenol-Rich Foods Slow Epigenetic Aging?

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc. A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure o

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …

Aging Feb 15, 2026

47 Early

Design 12

Sample 6

Peer Review 13

Replication 7

Transparency 9

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5. A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges impo

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …

r/Biohackers Feb 15, 2026

53 Promising

Design 9

Sample 10

Peer Review 12

Replication 9

Transparency 13

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to modera

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. The post claims just 9 minutes …

r/Biohackers Feb 15, 2026

50 Promising

Design 11

Sample 13

Peer Review 12

Replication 8

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

How Exercise Clears Damaged Cells and Reverses Muscle Aging

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity.

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. The post frames exercise as a cellular-level …

r/Nootropics Feb 15, 2026

32 Early

Design 9

Sample 4

Peer Review 8

Replication 5

Transparency 6

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

How healthy diets add years to your life—even if your genes say otherwise

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1. A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefit

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefits holding true regardless of …

Science advances Feb 15, 2026

65 Promising

Design 11

Sample 15

Peer Review 18

Replication 10

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How Mild Calorie Restriction Rewires Brown Fat to Stay Energetic

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. The

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. These coordinated metabolic …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb 15, 2026

40 Early

Design 6

Sample 7

Peer Review 13

Replication 5

Transparency 9

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Women's Alzheimer's Prevention: Lifestyle, Menopause, and Emerging Treatments

Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention tools while highlighting emerging pharmaceutical options like GLP-1 agonists and klotho. Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention

Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention tools while highlighting emerging pharmaceutical options like GLP-1 agonists and klotho. The conversation …

Peter Attia Feb 15, 2026

50 Promising

Design 13

Sample 6

Peer Review 7

Replication 11

Transparency 13

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Seed Oils vs. Lard: What the Science Actually Shows

Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as 'healthy' is misleading. Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that

Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as …

Peter Attia Feb 15, 2026

55 Promising

Design 13

Sample 8

Peer Review 9

Replication 11

Transparency 14

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Seed Oils and Longevity: Evidence-Based Analysis of Nutritional Harm Claims

Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against seed oils while Norton defends the evidence suggesting they are not uniquely harmful. Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against se

Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against seed oils while Norton defends …

Peter Attia Feb 15, 2026

44 Early

Design 13

Sample 0

Peer Review 8

Replication 9

Transparency 14

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Exercise, Heat, and Cold: Dr. Patrick's Healthspan Optimization Guide

Dr. Dr. Rhonda Patrick presents evidence that vigorous-intensity exercise is the most powerful anti-aging intervention available, reversing 20 years of heart aging in 2 years, with each unit improvement i

Dr. Rhonda Patrick presents evidence that vigorous-intensity exercise is the most powerful anti-aging intervention available, reversing 20 years of heart aging in 2 years, with each unit improvement in VO2 max adding ~45 days to …

FoundMyFitness Feb 15, 2026

60 Promising

Design 13

Sample 11

Peer Review 12

Replication 12

Transparency 12

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Vigorous Exercise May Be 4-10x More Effective Than Moderate Activity

This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing mortality risk. This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing m

This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing mortality risk. The hosts argue …

FoundMyFitness Feb 15, 2026

26 Early

Design 7

Sample 4

Peer Review 5

Replication 4

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Visceral Fat Reduction and Lifespan: Mike Lustgarten's 3-Year Self-Tracking

This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low viscera

This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. ~1300g expected for …

Mike Lustgarten Feb 15, 2026

43 Early

Design 10

Sample 5

Peer Review 11

Replication 6

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Beta-Hydroxybutyrate: The Ketone Link to Longevity in Mice

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through gl

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. The video presents mouse model data showing BHB's …

Mike Lustgarten Feb 15, 2026

48 Early

Design 11

Sample 9

Peer Review 8

Replication 9

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Life Expectancy Gains Are Slowing—Here's Why

A PNAS study shows that life expectancy improvements in high-income countries have decelerated 37-52% for cohorts born 1939-2000, primarily because infant mortality is now near zero, eliminating the easy statistical gains of the 20th century. …

r/longevity Feb 15, 2026

34 Early

Design 8

Sample 6

Peer Review 7

Replication 7

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

1,500 Days Sober: Biomarkers Show Dramatic Health Recovery After Alcoholism

A 34-year-old documents remarkable biomarker improvements (biological age 23. A 34-year-old documents remarkable biomarker improvements (biological age 23.7, normalized liver function, excellent metabolic markers) after 1,500 days of sobriety combined with consistent lifestyle

A 34-year-old documents remarkable biomarker improvements (biological age 23.7, normalized liver function, excellent metabolic markers) after 1,500 days of sobriety combined with consistent lifestyle practices. The author emphasizes that fundamentals like alcohol elimination, cardio, sleep, …

r/Biohackers Feb 15, 2026

28 Early

Design 3

Sample 2

Peer Review 4

Replication 5

Transparency 14

How we score →