How a Parkinson's protein controls brain cell connections through structural remodeling

Researchers discovered that LRRK2, a protein linked to Parkinson's disease, plays a critical role in strengthening connections between neurons by reorganizing the cellular skeleton in response to brain growth signals. This work identifies synaptic dysfunction—not …

28 Early
Design 6
Sample 5
Peer Review 3
Replication 5
Transparency 9

How senescent cells dump their waste and why that might fuel cancer and aging

Researchers discovered that aging cells shed large fragments containing damaged organelles through a process that keeps the cells alive but deposits cellular debris that activates cancer and wound-healing programs. This reveals a double-edged mechanism: senescent …

29 Early
Design 5
Sample 8
Peer Review 3
Replication 4
Transparency 9

AI System Identifies 500+ Aging-Slowing Interventions Hidden in Existing Data

Researchers used AI agents to reanalyze millions of existing molecular datasets (methylation and RNA sequencing) through the lens of aging clocks, discovering over 500 interventions that appear to reduce biological age—including drugs like ouabain and …

48 Early
Design 10
Sample 15
Peer Review 5
Replication 7
Transparency 11