This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …
Researchers found that SARS-CoV-2 infection disables a cellular growth regulator called mTORC1, which causes host cells to stop making most of their own proteins while still allowing viral proteins to be produced. This mechanism was …
Researchers discovered that telomerase doesn't just work on the finished ends of chromosomes—it also repairs breaks that happen *during* DNA replication at chromosome tips, and does so much more frequently than previously thought. This challenges …
This study reveals how a fungus (Neurospora crassa) uses two cellular signaling pathways to coordinate cell fusion—one pathway activates the machinery for building cellular structures, while the other aims that machinery at the right location. …
Researchers developed FastGxC, a computational method that finds genes whose activity changes depending on tissue or cell type context—a key mechanism in disease risk. The tool is a million times faster than existing approaches and …
Researchers used advanced imaging and mass spectrometry to map how insulin receptors behave in muscle cells, discovering they travel via two different cellular pathways—one involving caveolin and one involving clathrin. This fundamental understanding of insulin …
Researchers created a computational model that simulates how fruit fly larvae move, navigate, and learn—combining physics-based locomotion with neural circuits and behavior. This tool could help neuroscientists test theories about how brains control behavior without …
Researchers trained artificial intelligence models to automatically identify different kidney cell structures using a simple imaging technique, without needing stains or labels. This tool could help scientists understand how kidneys age and develop better tests …
Researchers created a mathematical model showing how two inhibitor proteins (Dickkopf) and Wnt signalling interact to form Hydra's body axis through mutual inhibition rather than the classical activator-inhibitor mechanism. This provides a mechanistic blueprint for …
Researchers experimentally warmed nests of wild great tits by 2°C during development and found the chicks showed accelerated telomere shortening—a cellular aging marker—despite normal growth. This suggests climate warming could speed up aging in birds, …
Researchers found that a protein called TFAM, which manages mitochondria in regulatory T cells (immune cells that calm inflammation), is critical for preventing age-related systemic inflammation and physical decline. When mitochondrial function deteriorates in these …
This is a ornithological ecology study about where Black Woodpeckers excavate cavities in French forests—it has no relevance to human aging, lifespan, or longevity research. The analysis examined landscape and forest composition factors across three …
Researchers grew human pluripotent stem cells on circular patterns and watched them spontaneously organize into distinct midbrain and hindbrain regions—without being explicitly programmed to do so. This self-organizing system could help screen for birth defects …
This meta-analysis of 80 brain imaging studies identifies which research methods reliably detect the neural circuits involved in delay discounting—the tendency to prefer immediate rewards over future ones. The findings suggest that future studies should …
This meta-analysis of 45 neuroimaging studies (1,273 participants) identified distinct brain regions that process rewards and task difficulty separately, then integrate them to decide whether mental effort is worth the reward. The findings clarify how …