Aging is associated with increased oxidative stress, which leads to pathological vulnerability. Spermidine is a ubiquitous natural polyamine found across all living organisms studied so far and present in multiple food sources. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentration and age-related organ degeneration has been proposed. We outline recent studies that address the potential contribution of spermidine to geroprotection, with a perspective of advancing spermidine towards clinical trials.
Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases.
TL;DR
Aging is associated with increased oxidative stress, which leads to pathological vulnerability. Spermidine is a ubiquitous natural polyamine found across all living organisms studied so far and present in multiple food sources. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentration and age-related organ degeneration has been proposed. We outline recent studies that address the potential contribution of spermidine to geroprot
Credibility Assessment
Preliminary — 43/100
Study Design
Rigor of the research methodology
5/20
Sample Size
Whether the study was sufficiently powered
7/20
Peer Review
Review status and journal reputation
15/20
Replication
Has this finding been independently reproduced?
6/20
Transparency
Funding disclosure and data availability
10/20
Overall
Sum of all five dimensions
43/100
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