Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression. Histone lactylation, a recent modification in the field of epigenetic regulation, directly associates metabolic products-lactate-with chromatin modifications, revealing how cellular metabolism regulates the epigenetic landscape. In this review, we discuss the effects of histone lactylation on transcription and its metabolic regulatory mechanisms, explore the interplay between subnuclear metabolic microdomains and histone acetylation, and highlight the specific 'writing,' 'erasing,' and 'reading' enzymes involved in histone lactylation. Additionally, we discuss the physiological functions and recent advancements in the understanding of histone lactylation in disease progression, emphasizing its scientific significance for future research.
Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism.
TL;DR
Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression. Histone lactylation, a recent modification in the field of epigenetic regulation, directly associates metabolic products-lactate-with chromatin modifications, revealing how cellular metabolism regulates the epigenetic landscape. In this r
Credibility Assessment
Preliminary — 46/100
Study Design
Rigor of the research methodology
5/20
Sample Size
Whether the study was sufficiently powered
7/20
Peer Review
Review status and journal reputation
18/20
Replication
Has this finding been independently reproduced?
6/20
Transparency
Funding disclosure and data availability
10/20
Overall
Sum of all five dimensions
46/100
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