Machine learning in aging, drug discovery, protein folding, and digital twins
UNLABELLED: Heat stress significantly disrupts physiological and molecular balance in poultry, leading to oxidative damage, inflammatory responses, and metabolic dysregulation. Among emerging solutions, phytogenic adaptogens have shown promise as natural agents that enhance resilience against …
Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …
Researchers created an unprecedented atlas of gene activity in 1,675 human muscle biopsies, identifying over 3,000 genes that change with age and discovering that genes linked to muscle wasting in elderly people look strikingly similar …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
Researchers identified a quantitative framework showing that aging proceeds in two distinct phases: a stable period followed by a transition to frailty marked by intestinal breakdown. They found that newly frail individuals face extreme early …
The unprecedented extension of the human lifespan necessitates a parallel evolution in how we quantify the quality of aging and its socioeconomic impact. Traditional metrics focusing on Healthspan (years free of disease) overlook the gradual …
Background Older age is widely considered a risk factor for post-acute sequelae of SARS-CoV-2 infection (PASC), typically attributed to immunosenescence and inflammaging. However, whether this association reflects intrinsic biological ageing or accumulated comorbidity burden remains …
Background: Intrinsic capacity (IC) is a key marker of healthy ageing, which captures an individuals physical and mental capacities, measured across five domains: cognitive, locomotor, psychological, vitality, and sensory. Although genetic factors are known to …
Ageing of human skin is driven in part by cumulative damage to extracellular matrix (ECM) proteins, resulting in wrinkles, laxity, and reduced capacity to heal. Bioactive peptide matrikines are promising therapeutic agents capable of stimulating …
Tissue structure, the organization of cells, vasculature and extracellular matrix, underpins organ function. Yet how it deteriorates with age remains largely uncharacterized. Current aging research focuses primarily on molecular changes, missing this structural dimension. Here …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Ginsenoside Rg1 (Rg1), an active compound in Panax ginseng C. A. Meyer (ginseng), has shown potential to ameliorate age-related cell damage and extend lifespan in multiple model organisms. However, the precise molecular mechanisms of its …
Aging of hematopoietic stem and progenitor cells (HSPCs) impairs regenerative capacity and predisposes to hematological diseases. Here, we constructed a comprehensive single-cell transcriptomic atlas comprising 186,123 CD34+ HSPCs spanning early prenatal development (6 post-conception weeks) …
BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. Sleep disorders have emerged as an increasingly important but …
This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …
Researchers studied an unusually long-lived population of invasive bighead carp and found they survive at very high rates (>95% annually) but grow slowly, with implications for predicting how invasive species establish themselves. This work has …
Researchers synthesized a new class of hybrid molecules combining an anti-cancer drug scaffold (sulfadiazine) with a 5-oximidazoline ring structure, and found that one compound (7l) killed liver cancer cells in the lab and extended survival …
Researchers created a mathematical model showing how two inhibitor proteins (Dickkopf) and Wnt signalling interact to form Hydra's body axis through mutual inhibition rather than the classical activator-inhibitor mechanism. This provides a mechanistic blueprint for …
This meta-analysis of 80 brain imaging studies identifies which research methods reliably detect the neural circuits involved in delay discounting—the tendency to prefer immediate rewards over future ones. The findings suggest that future studies should …
This meta-analysis of 45 neuroimaging studies (1,273 participants) identified distinct brain regions that process rewards and task difficulty separately, then integrate them to decide whether mental effort is worth the reward. The findings clarify how …