Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ boosters, and the molecules in clinical trials right now.
In this study, the effect of dietary taurine (Tau) on the innate immune responses, digestive function, and mammalian target of rapamycin (RAPA; mTOR) signaling was investigated in coho salmon (Oncorhynchus kisutch). Coho salmon were fed …
Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that …
The increasing global burden of age-related diseases necessitates interventions that target the unified biological processes of aging, as outlined by the expanding framework of fourteen interconnected hallmarks. This review establishes nicotinamide adenine dinucleotide (NAD⁺) as …
Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …
The Interventions Testing Program (ITP) evaluated eleven compounds in genetically heterogeneous UM-HET3 mice to assess their potential to extend lifespan. These interventions included both novel agents and previously tested compounds administered at novel doses or …
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
Melanocyte proliferation gene 1 (MYG1) has been implicated in cellular metabolic regulation; however, its role in cardiomyocyte metabolic reprogramming during acute myocardial infarction (AMI) remains unclear. In this study, a rat AMI model was established, …
Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …
Aging poses a growing global health burden, creating an urgent need for effective interventions. This study reveals that fenofibrate, a clinically approved drug for hyperlipidemia, exerts significant anti-aging effects by targeting fundamental aging processes. We …
Researchers fed pregnant fruit flies a high-fat diet supplemented with tauroursodeoxycholic acid (TUDCA), a bile acid derivative, and found their offspring lived ~19% longer with better stress resistance and mitochondrial health. The lifespan benefit depended …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Alzheimer's disease (AD) affects approximately 50 million individuals worldwide and is projected to triple by 2050. Ligustilide is a naturally occurring compound with varied pharmacological actions. Ligustilide has been reported to ameliorate AD by inhibiting …
The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …
A leading theory for how psychedelics are able to produce robust clinical improvement and preclinical behavioral changes is that psychedelics act through neuroplastic mechanisms to induce lasting structural and functional alterations in neural circuits. However, …
Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …
Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy …
Cardiometabolic gene-target drugs such as Glucagon-Like Peptide 1 Receptor agonists are used extensively, yet risks and repurposing have not been systematically evaluated across a comprehensive set of diseases. We use Phenome-wide Mendelian Randomization to test …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …