Researchers discovered that a protein called LHX1 silences STING, a cellular alarm system that triggers senescence (aging) and tumor suppression in head and neck cancer cells. Disrupting LHX1 reactivates this alarm, causing cancer cells to …
Researchers found that a protein called TIMP2 is overproduced after acute kidney injury and actively drives the transition to chronic kidney disease by promoting cell aging and scarring. Deleting TIMP2 in kidney tubule cells in …
This study identifies why immune cells (NK cells) from older adults become ineffective at removing senescent fibroblasts—harmful aging cells that accumulate in tissues. The culprit is overactivity of a protein called Cdc42, which disrupts the …
Injection of healthy mitochondria into aged muscle tissue restored ATP production and contractile strength.
A combination of dasatinib and quercetin cleared senescent cells in aged mice, resulting in improved physical function and extended healthy lifespan by approximately 30%.