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Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues.

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent drug, 28i avoids dangerous …

Journal of medicinal chemistry Feb 15, 2026

39 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant.

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities.

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective dietary strategies against X-ray-induced male reproductive system damage, this …

Food & function Feb 15, 2026

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Leonurine Attenuates Ischemia-Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …

Phytotherapy research : PTR Feb 15, 2026

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Observational PubMed

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores.

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …

Journal of ethnopharmacology Feb 15, 2026

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Can Two Plant Compounds Together Slow Brain Aging in Rats?

Researchers tested whether squalene and saponin—two natural compounds—could reduce aging-related damage in rat brains exposed to a chemical that mimics aging. The combination treatment reduced oxidative stress markers and boosted protective proteins, but this is …

Biogerontology Feb 12, 2026

42 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Medicinal Mushroom Extract Extends Lifespan and Stress Resistance in Worms

A polysaccharide extract from Ganoderma atrum fungus extended lifespan by ~23% in C. elegans and improved markers of healthy aging by activating two key longevity pathways (IIS and MAPK). While the findings are promising for …

Food research international (Ottawa, Ont.) Feb 12, 2026

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How polyamines control aging: New insights into a cellular anti-aging mechanism

This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …

Amino acids Feb 12, 2026

36 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

How glycine may slow aging by boosting mitochondrial metabolism

Researchers found that glycine supplementation extended lifespan in fruit flies and improved age-related damage in rats by activating a protein called Nmdmc that enhances mitochondrial energy production and DNA repair. The mechanism involves reshaping how …

Free radical biology & medicine Feb 12, 2026

37 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

How a Citrus Compound Reverses Brain Aging in Rats

Researchers used a rat model combining radiation and a sugar that accelerates aging to test naringin, a natural compound from citrus fruits. Naringin reduced markers of brain aging, inflammation, and cell death in treated animals, …

Journal of biochemical and molecular toxicology Feb 12, 2026

36 Early

Verified Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Randomised Controlled Trial PubMed

Rapamycin Low-Dose Safety Profile in Healthy Elderly

Weekly low-dose rapamycin was well-tolerated in adults over 70, with improved immune function markers.

The Lancet Healthy Longevity Feb 12, 2026 n=150

81 Strong

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Randomised Controlled Trial PubMed

NAD+ Precursors Show Promise in Human Trials

NMN supplementation increased blood NAD+ levels by 40% in middle-aged adults, with improvements in insulin sensitivity.

Science Feb 12, 2026 n=80

74 Promising