Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation.

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal …

Journal of agricultural and food chemistry Feb 15, 2026
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Can tongue strength predict healthy aging in older adults?

This paper proposes that tongue pressure—how forcefully someone can press their tongue against the roof of their mouth—may be a useful marker of overall frailty and longevity in older people. The authors argue measuring tongue …

Geriatrics & gerontology international Feb 12, 2026
30 Early
Design 4
Sample 2
Peer Review 11
Replication 4
Transparency 9
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Do nail changes in older adults signal low zinc levels?

Researchers compared nail structure and zinc content in 64 older adults with and without visible nail changes, finding no significant difference in zinc levels between the two groups. The study suggests nail aging is more …

PeerJ Feb 12, 2026
43 Early
Design 8
Sample 8
Peer Review 11
Replication 5
Transparency 11
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Single-Cell Aging Clocks: Measuring Age at the Cellular Level

This review examines new tools called single-cell aging clocks that measure biological age in individual cells rather than averaging across thousands of cells at once. These tools reveal that aging varies dramatically between cell types …

Ageing research reviews Feb 12, 2026
36 Early
Design 4
Sample 2
Peer Review 13
Replication 7
Transparency 10
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Rethinking What Aging Trajectory Tests Actually Measure

This commentary questions whether JST-IC trajectory patterns genuinely reflect aging decline or instead capture stable life-course abilities shaped by education, technology familiarity, and generational factors. The authors argue researchers need to reconsider how to interpret …

Geriatrics & gerontology international Feb 12, 2026
30 Early
Design 4
Sample 2
Peer Review 11
Replication 4
Transparency 9
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

How Aging and High Blood Pressure Damage Kidneys Through Cellular Senescence

Researchers found that kidney damage from aging and hypertension is associated with accumulation of senescent (aging) cells in the glomeruli—the kidney's filtering units. The study identifies specific molecular markers of cellular senescence that correlate with …

Physiological reports Feb 12, 2026
41 Early
Design 8
Sample 8
Peer Review 11
Replication 5
Transparency 9
How we score →
Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Blood Pressure Changes May Signal Cognitive and Functional Decline in the Very Elderly

In adults aged 85+, researchers used advanced pattern-matching analysis to find that drops in blood pressure preceded cognitive decline, while rises in blood pressure preceded difficulty with daily activities. This suggests BP changes in very …

Age and ageing Feb 12, 2026
51 Promising
Design 11
Sample 10
Peer Review 15
Replication 6
Transparency 9
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

How Mouth Bacteria May Link to Frailty and Cognitive Decline in Older Adults

This is a protocol paper announcing a planned scoping review that will search the scientific literature for evidence connecting oral microbiome composition to three common aging syndromes: frailty, muscle loss, and cognitive disorders in people …

BMJ open Feb 12, 2026
34 Early
Design 4
Sample 2
Peer Review 14
Replication 2
Transparency 12
How we score →
Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Building a 10,000-person aging study in Northern Italy: methods and early findings

Researchers in Italy are establishing a large longitudinal cohort study to track how people age, combining detailed health assessments with genetic and protein measurements. Early results show the approach works and reveal links between frailty …

BMJ open Feb 12, 2026
51 Promising
Design 11
Sample 8
Peer Review 15
Replication 6
Transparency 11
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

A Faster Brain Test for Spotting Early Dementia: New Scoring Standards

Researchers validated a quick executive function test (TCST) that can reliably distinguish normal aging from Alzheimer's disease with 84% accuracy. The study provides age-adjusted scoring norms that make the test more clinically useful for early …

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists Feb 12, 2026
45 Early
Design 8
Sample 10
Peer Review 13
Replication 5
Transparency 9
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Why men and women age differently: A roadmap for future research

This essay identifies critical gaps in our understanding of why males and females show different rates of age-related diseases, infections, and vaccine responses—differences driven by sex hormones and genetics. The authors outline priority research areas …

PLoS biology Feb 12, 2026
34 Early
Design 5
Sample 2
Peer Review 14
Replication 2
Transparency 11
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Brain noise and working memory: why older adults' brains work differently

This study found that older adults show increased 'neural noise' (flatter EEG patterns) compared to younger adults during working memory tasks, and this noise correlates with less efficient brain processing. The findings suggest aging brains …

Psychophysiology Feb 12, 2026
44 Early
Design 8
Sample 8
Peer Review 13
Replication 6
Transparency 9
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Why Brain Structure Changes Affect Sleep in Alzheimer's Disease

Researchers found that the health of a small brain region called the locus coeruleus is linked to deep sleep loss in aging and Alzheimer's disease, with stronger effects in women. The study suggests that protecting …

Alzheimer's & dementia : the journal of the Alzheimer's Association Feb 12, 2026
46 Early
Design 11
Sample 7
Peer Review 14
Replication 5
Transparency 9
How we score →
Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

Blood Proteins of Centenarians Reveal Secrets of Extreme Longevity

Researchers analyzed blood proteins from Swiss centenarians and discovered 37 proteins associated with a 'younger' profile that may explain why some people live to 100 and stay healthy. By comparing centenarian patterns across two independent …

Aging cell Feb 12, 2026
56 Promising
Design 11
Sample 8
Peer Review 15
Replication 12
Transparency 10
How we score →
Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

How Gum Disease Ages Your Body: A Link to Earlier Death

Researchers found that moderate to severe periodontitis (gum disease) is associated with higher mortality risk, and this connection appears to work partly through accelerated biological aging—measured by two epigenetic clocks (PhenoAge and KDM). While biological …

Clinical and experimental dental research Feb 12, 2026
50 Promising
Design 11
Sample 14
Peer Review 11
Replication 5
Transparency 9
How we score →