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Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Aging Drives Alzheimer's Disease: A Molecular Roadmap

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms.

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that targeting aging mechanisms themselves, rather than individual AD symptoms, could …

Cellular signalling Feb 15, 2026

37 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Can crocin-enriched tomatoes slow aging and protect the brain?

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age.

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. While promising in this animal model, the findings need human testing …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb 15, 2026

37 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How aging immune cells drive aging throughout the body

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body.

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restoring immune function could be a …

Nature reviews. Immunology Feb 15, 2026

45 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Hedgehog Signaling Might Combat Aging Across Multiple Organs

This review synthesizes evidence that activating Hedgehog signaling—a developmental pathway—may counteract hallmarks of aging like stem cell exhaustion and chronic inflammation across brain, liver, heart, and other tissues. While preclinical results are promising, the authors …

Experimental & molecular medicine Feb 13, 2026

35 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How a Damaged Protein Spreads Aging Signals Through Your Body

Researchers discovered that HMGB1, a protein released by aging cells, can trigger aging in healthy cells when it's in a specific damaged form—but not when it's oxidized. Blocking this protein in mice reduced aging markers …

Metabolism: clinical and experimental Feb 13, 2026

38 Early

Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Nine Core Mechanisms Explain Why We Age

This landmark review identifies nine interconnected biological processes—from DNA damage to stem cell failure—that drive aging across species. Rather than discovering new biology, it synthesizes existing knowledge into a unifying framework to guide future drug …

Cell Feb 13, 2026

55 Promising

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Why Sertoli Cells Age Faster Than Sperm-Making Cells—And What It Means for Male Fertility

This review reveals that Sertoli cells—the support cells in testes—age faster and suffer more genetic disruption than the germ cells they nurture, accumulating damage from oxidative stress, mitochondrial dysfunction, and epigenetic changes. Understanding how these …

Biogerontology Feb 12, 2026

32 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Common Molecular Signature of Muscle Wasting Across Cancer, Steroids, and Aging

Researchers discovered that while different causes of muscle wasting (cancer, steroid use, and aging) trigger mostly distinct molecular changes, they all share one common signature: reduced chemical modification of a protein called Lrpprc. Restoring this …

Journal of cachexia, sarcopenia and muscle Feb 12, 2026

47 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

How Asthma Accelerates Immune Cell Aging in the Lungs

Researchers found that asthma patients have abnormally high levels of aged CD4+ T cells (immune cells), driven by type 2 inflammation. When transplanted into asthmatic mice, these aged immune cells worsened inflammation, suggesting that blocking …

Journal of Zhejiang University. Science. B Feb 12, 2026

45 Early

Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro PubMed

Wild Mediterranean mice show superior lysosome function—a clue for aging research

Researchers discovered that fibroblasts from wild Mediterranean mice (Mus spretus) have higher lysosomal activity and less cellular senescence than cells from lab mice, suggesting that wild species may offer natural blueprints for treating age-related lysosomal …

Biology letters Feb 12, 2026

39 Early

Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro PubMed

How tissue scaffolds reprogram immune cells through tiny vesicles

Researchers discovered that tiny nanoparticles embedded in tissue scaffolds can enter immune cell precursors in bone marrow and reprogram their genes to reduce inflammation—and these effects persist even after the cells fully mature. This suggests …

Science advances Feb 12, 2026

42 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How immune signaling molecules drive aging: CXC chemokines and cellular senescence explained

This review examines how CXC chemokines—signaling proteins released by aging cells—contribute to age-related diseases and cancer. The authors propose these molecules could become biomarkers for aging and targets for new longevity therapies, though most evidence …

Biogerontology Feb 12, 2026

37 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How immune cells in the brain age and a new way to slow that process

This review highlights how T cells in the brain show signs of exhaustion as we age, and describes a promising engineered immune protein that could restore brain immune function by rebalancing inflammatory signals. The work …

Immunity Feb 12, 2026

37 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How IL-2 signals B cells to fight inflammation and may protect against autoimmune disease

Researchers discovered that IL-2 signaling in B cells activates a regulatory program that produces anti-inflammatory IL-10, especially in aging B cells. In a mouse model of multiple sclerosis, this pathway was protective—loss of IL-2 signaling …

Immunity Feb 12, 2026

45 Early

Promising Cellular — Research on cellular-level aging mechanisms Observational PubMed

How the brain's energy pathways change across regions and lifespan

Researchers mapped five key energy-producing pathways across the human brain using genetic data, finding they're distributed differently in sensory areas and follow distinct aging patterns—peaking in childhood for energy production, but declining throughout life for …

PLoS biology Feb 12, 2026

53 Promising