Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. Sleep disorders have emerged as an increasingly important but …

38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10

New anti-cancer compounds show promise in mouse models of liver cancer

Researchers synthesized a new class of hybrid molecules combining an anti-cancer drug scaffold (sulfadiazine) with a 5-oximidazoline ring structure, and found that one compound (7l) killed liver cancer cells in the lab and extended survival …

36 Early
Design 6
Sample 5
Peer Review 11
Replication 5
Transparency 9

How a 30+ Year Old Fish Reveals Secrets About Invasive Species Survival

Researchers studied an unusually long-lived population of invasive bighead carp and found they survive at very high rates (>95% annually) but grow slowly, with implications for predicting how invasive species establish themselves. This work has …

38 Early
Design 8
Sample 5
Peer Review 11
Replication 5
Transparency 9

Eight genes predict survival and immunotherapy response in liver cancer

Researchers identified eight genes linked to cellular senescence that can predict which liver cancer patients will survive longer and respond to immunotherapy. The findings come from analyzing gene expression patterns in individual cancer cells and …

46 Early
Design 9
Sample 13
Peer Review 11
Replication 4
Transparency 9

A faster way to map protein modifications across aging tissues

Researchers developed MuPPE, a streamlined platform that analyzes three types of protein modifications (glycosylation, phosphorylation, and overall protein levels) from a single tissue sample in 4 hours instead of 32 hours. When applied to aging …

48 Early
Design 7
Sample 6
Peer Review 18
Replication 6
Transparency 11