How the retina ages: A macaque model reveals layer-by-layer changes from youth to old age

Researchers used imaging in 285 macaques and postmortem human eyes to map how the retina thickens during development but thins with age—a pattern that could help us understand age-related vision loss. The findings suggest macaques …

49 Early
Design 6
Sample 12
Peer Review 16
Replication 5
Transparency 10

Simple Blood Tests May Help Predict COVID-19 Severity in Older Adults

This narrative review examines whether three readily available blood markers—lymphopenia, neutrophilia, and the neutrophil-to-lymphocyte ratio (NLR)—can reliably indicate immune aging and predict severe COVID-19 outcomes in elderly patients. The authors conclude these markers consistently correlate …

32 Early
Design 4
Sample 2
Peer Review 11
Replication 7
Transparency 8

People with schizophrenia show signs of accelerated aging across brain and body

Researchers found that people diagnosed with schizophrenia age faster on a biological level than the general population, using a novel brain imaging measure of aging. This finding, replicated across four independent datasets, could explain why …

59 Promising
Design 8
Sample 13
Peer Review 14
Replication 13
Transparency 11

Does Brain Antioxidant Level Predict Cognitive Performance in Aging?

This editorial discusses a new study finding that higher glutathione (an antioxidant) levels in the brain correlate with better cognitive performance in older adults, measured using brain imaging. However, the authors note that findings across …

36 Early
Design 5
Sample 2
Peer Review 13
Replication 6
Transparency 10