Disputed Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary Reddit

NAD Precursors: What Science Says About NR vs NMN Supplements

This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is exercise recovery. This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is ex

This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is exercise …

r/Biohackers Feb 16, 2026

23 Weak

Design 4

Sample 3

Peer Review 5

Replication 5

Transparency 6

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

Urolithin A and cardiovascular health: preclinical promise meets human biomarker data

A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy older adults. A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy olde

A Reddit user shares a peer-reviewed study showing urolithin A (a pomegranate metabolite) improves mitochondrial function in animal models and reduces cardiovascular disease biomarkers in healthy older adults. The discussion covers mechanism, bioavailability challenges, and …

r/Biohackers Feb 16, 2026

44 Early

Design 11

Sample 7

Peer Review 9

Replication 8

Transparency 9

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Randomised Controlled Trial Reddit

Can Polyphenol-Rich Foods Slow Epigenetic Aging?

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc. A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure o

A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …

Aging Feb 15, 2026

47 Early

Design 12

Sample 6

Peer Review 13

Replication 7

Transparency 9

How we score →

Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction

Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Blocking a key enzyme (v-ATPase) with an inhibi

Researchers discovered that lysosomes become hyperactive and damaged in aging blood stem cells, driving decline in immune function and blood production. Blocking a key enzyme (v-ATPase) with an inhibitor restored youthful function and dramatically improved …

r/longevity Feb 15, 2026

60 Promising

Design 13

Sample 12

Peer Review 11

Replication 12

Transparency 12

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5. A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges impo

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …

r/Biohackers Feb 15, 2026

53 Promising

Design 9

Sample 10

Peer Review 12

Replication 9

Transparency 13

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to modera

A Reddit discussion summarizes findings from a Nature Biobank study showing vigorous-intensity exercise provides dramatically greater mortality and disease risk reduction per minute compared to moderate or light activity. The post claims just 9 minutes …

r/Biohackers Feb 15, 2026

50 Promising

Design 11

Sample 13

Peer Review 12

Replication 8

Transparency 6

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

How Exercise Clears Damaged Cells and Reverses Muscle Aging

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity.

A Reddit post discusses a study showing that exercise removes senescent (damaged) cells from muscle tissue, reactivates stem cells, and improves insulin sensitivity in middle-aged adults with obesity. The post frames exercise as a cellular-level …

r/Nootropics Feb 15, 2026

32 Early

Design 9

Sample 4

Peer Review 8

Replication 5

Transparency 6

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Reversing liver scarring with reprogramming mRNA in mice

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state. Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state. This proof-of-concept study suggests mRNA-based cellular rejuvenation …

Journal of controlled release : official journal of the Controlled Release Society Feb 15, 2026

41 Early

Design 6

Sample 8

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Aging Drives Alzheimer's Disease: A Molecular Roadmap

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that target

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that targeting aging mechanisms themselves, rather than individual AD symptoms, could …

Cellular signalling Feb 15, 2026

37 Early

Design 4

Sample 2

Peer Review 14

Replication 7

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent dr

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent drug, 28i avoids dangerous …

Journal of medicinal chemistry Feb 15, 2026

39 Early

Design 6

Sample 5

Peer Review 14

Replication 5

Transparency 9

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training

Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. In studies, lowering this protein in mice dramatica

Researchers discovered that IGFBP7, a protein linked to cellular aging, may act as a 'brake' on how much fitness people gain from exercise training. In studies, lowering this protein in mice dramatically improved their exercise …

medrxiv (preprint) Feb 15, 2026

25 Early

Design 7

Sample 5

Peer Review 3

Replication 4

Transparency 6

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How to Reverse Age-Related Immune System Decline

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors su

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors survey promising rejuvenation strategies—from …

Science advances Feb 15, 2026

40 Early

Design 4

Sample 2

Peer Review 17

Replication 7

Transparency 10

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

How healthy diets add years to your life—even if your genes say otherwise

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1. A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefit

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefits holding true regardless of …

Science advances Feb 15, 2026

65 Promising

Design 11

Sample 15

Peer Review 18

Replication 10

Transparency 11

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Longevity and Innovation: Cardiac Resynchronization Therapy in a 100-Year-Old Patient With Severe Heart Failure-A 4-Year Follow-Up.

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. This case report presents a

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. This case report presents a 100-year-old male with a history of atrial fibrillation …

Case reports in cardiology Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Natural Products Targeting the PI3K/Akt/mTOR-Mediated Autophagy Pathway in Cancer Therapy: Recent Advances and Clinical Perspectives.

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving prolif

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Natural products offer a …

Journal of natural products Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →