Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Inflammatory milieu and role of epigenetic modifications in high-grade serous ovarian cancer.

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. The disease progression

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. The disease progression is largely influenced by a dynamic tumor microenvironment (TME), …

Clinical epigenetics Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Orthodontic treatment positively influences behavior and perception on age recognition.

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. MATERIALS AND METHODS: Adult laypeople (N = 80; 19-84 years) were asked to "estimate the ag

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. MATERIALS AND METHODS: Adult laypeople (N = 80; 19-84 years) were asked to "estimate the age" and "select the younger …

The Angle orthodontist Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant.

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective die

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective dietary strategies against X-ray-induced male reproductive system damage, this …

Food & function Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-prote

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal …

Journal of agricultural and food chemistry Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research a

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. Sleep disorders have emerged as an increasingly important but …

Andrology Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Revision Neck Lift Surgery: A Systematic Review of Indications, Techniques, and Outcomes.

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures. BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate manageme

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures. Evidence remains sparse and heterogeneous. …

Aesthetic plastic surgery Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Predictors of Readiness to Engage in Advance Care Planning Among Older Adults With Serious Illness: Baseline Findings From the EQUAL ACP Study.

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. However, disparities in ACP engagement persist

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. However, disparities in ACP engagement persist, particularly among African American older adults. This study examined …

Journal of the American Geriatrics Society Feb 15, 2026

44 Early

Design 5

Sample 7

Peer Review 16

Replication 6

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Leonurine Attenuates Ischemia-Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …

Phytotherapy research : PTR Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Can crocin-enriched tomatoes slow aging and protect the brain?

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. While

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. While promising in this animal model, the findings need human testing …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb 15, 2026

37 Early

Design 6

Sample 6

Peer Review 11

Replication 5

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How aging immune cells drive aging throughout the body

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restor

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restoring immune function could be a …

Nature reviews. Immunology Feb 15, 2026

45 Early

Design 4

Sample 2

Peer Review 18

Replication 10

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How Mild Calorie Restriction Rewires Brown Fat to Stay Energetic

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. The

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. These coordinated metabolic …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb 15, 2026

40 Early

Design 6

Sample 7

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Observational PubMed

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. H

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …

Journal of ethnopharmacology Feb 15, 2026

41 Early

Design 8

Sample 6

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Why Women Develop Alzheimer's Earlier: Brain Changes Begin in Midlife

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences alone. Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male pr

Lisa Mosconi, a neuroscientist studying sex differences in Alzheimer's disease, argues that women show earlier pathological brain changes in midlife compared to men, and that the 2:1 female-to-male prevalence cannot be explained by longevity differences …

Peter Attia Feb 15, 2026

48 Early

Design 13

Sample 7

Peer Review 8

Replication 9

Transparency 11

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Women's Alzheimer's Prevention: Lifestyle, Menopause, and Emerging Treatments

Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention tools while highlighting emerging pharmaceutical options like GLP-1 agonists and klotho. Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention

Lisa Mosconi discusses sex-specific Alzheimer's prevention strategies for midlife women, emphasizing behavioral interventions (exercise, sleep, nutrition, stress management) as the primary prevention tools while highlighting emerging pharmaceutical options like GLP-1 agonists and klotho. The conversation …

Peter Attia Feb 15, 2026

50 Promising

Design 13

Sample 6

Peer Review 7

Replication 11

Transparency 13

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. The discussion covers the emerging ability to detect precli

Peter Attia interviews neuroscientist Lisa Mosconi about how hormonal transitions in women affect Alzheimer's disease risk and brain health. The discussion covers the emerging ability to detect preclinical Alzheimer's disease through biomarkers and imaging before …

Peter Attia Feb 15, 2026

50 Promising

Design 12

Sample 8

Peer Review 8

Replication 11

Transparency 11

How we score →