Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Reversing liver scarring with reprogramming mRNA in mice

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state. Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative

Researchers used specially designed lipid nanoparticles to deliver reprogramming genes (OSK) directly to liver cells in mice with fibrosis, successfully converting scarred cells back to a regenerative state. This proof-of-concept study suggests mRNA-based cellular rejuvenation …

Journal of controlled release : official journal of the Controlled Release Society Feb 15, 2026

41 Early

Design 6

Sample 8

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Aging Drives Alzheimer's Disease: A Molecular Roadmap

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that target

This review explains how aging accelerates Alzheimer's disease by disrupting multiple biological systems—from amyloid clearance to immune function to circadian rhythms. The authors propose that targeting aging mechanisms themselves, rather than individual AD symptoms, could …

Cellular signalling Feb 15, 2026

37 Early

Design 4

Sample 2

Peer Review 14

Replication 7

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent dr

Researchers engineered a new compound called 28i that inhibits an enzyme (MDH2) linked to aging, extending lifespan in worms and reducing aging markers in mouse cells and tissues. Unlike its parent drug, 28i avoids dangerous …

Journal of medicinal chemistry Feb 15, 2026

39 Early

Design 6

Sample 5

Peer Review 14

Replication 5

Transparency 9

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How to Reverse Age-Related Immune System Decline

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors su

This review examines why the thymus (a gland that produces immune cells) shrinks with age and stops making T cells effectively, leaving older adults vulnerable to infections and cancer. The authors survey promising rejuvenation strategies—from …

Science advances Feb 15, 2026

40 Early

Design 4

Sample 2

Peer Review 17

Replication 7

Transparency 10

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

How healthy diets add years to your life—even if your genes say otherwise

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1. A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefit

A study of over 100,000 UK adults found that five well-known healthy eating patterns—from Mediterranean to plant-based diets—were each associated with 1.5–3 extra years of life by age 45, with benefits holding true regardless of …

Science advances Feb 15, 2026

65 Promising

Design 11

Sample 15

Peer Review 18

Replication 10

Transparency 11

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Longevity and Innovation: Cardiac Resynchronization Therapy in a 100-Year-Old Patient With Severe Heart Failure-A 4-Year Follow-Up.

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. This case report presents a

Cardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with severe left ventricular systolic dysfunction (LVSD) and electrical dyssynchrony. This case report presents a 100-year-old male with a history of atrial fibrillation …

Case reports in cardiology Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Natural Products Targeting the PI3K/Akt/mTOR-Mediated Autophagy Pathway in Cancer Therapy: Recent Advances and Clinical Perspectives.

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving prolif

Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Natural products offer a …

Journal of natural products Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Inflammatory milieu and role of epigenetic modifications in high-grade serous ovarian cancer.

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. The disease progression

High-grade serous ovarian cancer (HGSOC) is often diagnosed at advanced stages (III/IV), with approximately 80% of patients experiencing relapse due to therapeutic resistance. The disease progression is largely influenced by a dynamic tumor microenvironment (TME), …

Clinical epigenetics Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Orthodontic treatment positively influences behavior and perception on age recognition.

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. MATERIALS AND METHODS: Adult laypeople (N = 80; 19-84 years) were asked to "estimate the ag

OBJECTIVES: To investigate how smiles and occlusion influence behavioral response and the perception of age. MATERIALS AND METHODS: Adult laypeople (N = 80; 19-84 years) were asked to "estimate the age" and "select the younger …

The Angle orthodontist Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant.

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective die

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities. Given the scarcity of safe and effective dietary strategies against X-ray-induced male reproductive system damage, this …

Food & function Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-prote

Protein restriction, while beneficial for maternal healthspan, poses risks to offspring development during lactation. This study investigated whether valine (Val) supplementation in maternal low-protein diets (LPDs) alleviates offspring developmental deficits via a gut-mammary axis. Maternal …

Journal of agricultural and food chemistry Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research a

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insufficiently integrated into andrological research and clinical practice. Sleep disorders have emerged as an increasingly important but …

Andrology Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Revision Neck Lift Surgery: A Systematic Review of Indications, Techniques, and Outcomes.

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures. BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate manageme

BACKGROUND: Revision neck lift is among the most technically demanding facial rejuvenation procedures and often addresses complex deformities related to aging, prior operations, or inadequate management of deep neck structures. Evidence remains sparse and heterogeneous. …

Aesthetic plastic surgery Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Predictors of Readiness to Engage in Advance Care Planning Among Older Adults With Serious Illness: Baseline Findings From the EQUAL ACP Study.

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. However, disparities in ACP engagement persist

BACKGROUND: Advance care planning (ACP) supports seriously ill individuals in identifying and communicating their values and preferences for future care. However, disparities in ACP engagement persist, particularly among African American older adults. This study examined …

Journal of the American Geriatrics Society Feb 15, 2026

44 Early

Design 5

Sample 7

Peer Review 16

Replication 6

Transparency 10

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Leonurine Attenuates Ischemia-Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …

Phytotherapy research : PTR Feb 15, 2026

38 Early

Design 5

Sample 7

Peer Review 10

Replication 6

Transparency 10

How we score →