This meta-analysis of 80 brain imaging studies identifies which research methods reliably detect the neural circuits involved in delay discounting—the tendency to prefer immediate rewards over future ones. The findings suggest that future studies should …
Researchers found that people diagnosed with schizophrenia age faster on a biological level than the general population, using a novel brain imaging measure of aging. This finding, replicated across four independent datasets, could explain why …
This meta-analysis of 45 neuroimaging studies (1,273 participants) identified distinct brain regions that process rewards and task difficulty separately, then integrate them to decide whether mental effort is worth the reward. The findings clarify how …
Researchers identified eight genes linked to cellular senescence that can predict which liver cancer patients will survive longer and respond to immunotherapy. The findings come from analyzing gene expression patterns in individual cancer cells and …
Researchers discovered that LRRK2, a protein linked to Parkinson's disease, plays a critical role in strengthening connections between neurons by reorganizing the cellular skeleton in response to brain growth signals. This work identifies synaptic dysfunction—not …
This study identifies why immune cells (NK cells) from older adults become ineffective at removing senescent fibroblasts—harmful aging cells that accumulate in tissues. The culprit is overactivity of a protein called Cdc42, which disrupts the …
This editorial discusses a new study finding that higher glutathione (an antioxidant) levels in the brain correlate with better cognitive performance in older adults, measured using brain imaging. However, the authors note that findings across …
Researchers discovered that aging cells shed large fragments containing damaged organelles through a process that keeps the cells alive but deposits cellular debris that activates cancer and wound-healing programs. This reveals a double-edged mechanism: senescent …
Researchers used AI agents to reanalyze millions of existing molecular datasets (methylation and RNA sequencing) through the lens of aging clocks, discovering over 500 interventions that appear to reduce biological age—including drugs like ouabain and …
This large national study found that exposure to common air pollutants—especially fine particulate matter (PM2.5)—increases the risk that older adults will develop mobility problems and makes it harder for them to bounce back to full …
Researchers developed MuPPE, a streamlined platform that analyzes three types of protein modifications (glycosylation, phosphorylation, and overall protein levels) from a single tissue sample in 4 hours instead of 32 hours. When applied to aging …
Researchers used a rat model combining radiation and a sugar that accelerates aging to test naringin, a natural compound from citrus fruits. Naringin reduced markers of brain aging, inflammation, and cell death in treated animals, …
Injection of healthy mitochondria into aged muscle tissue restored ATP production and contractile strength.
Limiting food intake to an 8-hour window reduced CRP and IL-6 levels by 25% in overweight adults.
Single injection of telomerase gene therapy extended telomeres by 20% in macaques.