Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Can crocin-enriched tomatoes slow aging and protect the brain?

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. While

Researchers fed fruit flies a crocin-enriched tomato extract and found it accelerated development, extended lifespan, preserved brain mitochondria, and maintained physical performance with age. While promising in this animal model, the findings need human testing …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb 15, 2026

37 Early

Design 6

Sample 6

Peer Review 11

Replication 5

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How aging immune cells drive aging throughout the body

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restor

This review explains how the immune system becomes dysfunctional with age, leading to chronic inflammation and organ damage that accelerates aging across the entire body. The authors argue that restoring immune function could be a …

Nature reviews. Immunology Feb 15, 2026

45 Early

Design 4

Sample 2

Peer Review 18

Replication 10

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How Mild Calorie Restriction Rewires Brown Fat to Stay Energetic

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. The

When male rats ate 15% fewer calories for just 2 weeks, their brown fat (heat-generating tissue) adapted by storing more fat droplets while maintaining its ability to burn energy and produce heat. These coordinated metabolic …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb 15, 2026

40 Early

Design 6

Sample 7

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Observational PubMed

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. H

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …

Journal of ethnopharmacology Feb 15, 2026

41 Early

Design 8

Sample 6

Peer Review 13

Replication 5

Transparency 9

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Rewinding the Brain's Age: Gene Therapy Restores Memory in Aging Mice

Researchers used a gene therapy technique to partially "reprogram" neurons that store memories in aged mice and Alzheimer's disease models, reversing signs of aging in those cells and restoring learning and memory to young-animal levels. …

Neuron Feb 13, 2026

45 Early

Design 6

Sample 8

Peer Review 16

Replication 5

Transparency 10

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Hedgehog Signaling Might Combat Aging Across Multiple Organs

This review synthesizes evidence that activating Hedgehog signaling—a developmental pathway—may counteract hallmarks of aging like stem cell exhaustion and chronic inflammation across brain, liver, heart, and other tissues. While preclinical results are promising, the authors …

Experimental & molecular medicine Feb 13, 2026

35 Early

Design 4

Sample 2

Peer Review 13

Replication 6

Transparency 10

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

How Partial Reprogramming Reverses Aging Marks on Key Genes

Researchers found that partial cellular reprogramming in aging mice reverses age-related chemical changes (DNA methylation patterns) specifically on genes controlled by a protein complex called PRC2. This suggests PRC2 may be a central hub controlling …

Molecular systems biology Feb 13, 2026

40 Early

Design 6

Sample 5

Peer Review 15

Replication 5

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How a Damaged Protein Spreads Aging Signals Through Your Body

Researchers discovered that HMGB1, a protein released by aging cells, can trigger aging in healthy cells when it's in a specific damaged form—but not when it's oxidized. Blocking this protein in mice reduced aging markers …

Metabolism: clinical and experimental Feb 13, 2026

38 Early

Design 6

Sample 6

Peer Review 12

Replication 5

Transparency 9

How we score →

Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Nine Core Mechanisms Explain Why We Age

This landmark review identifies nine interconnected biological processes—from DNA damage to stem cell failure—that drive aging across species. Rather than discovering new biology, it synthesizes existing knowledge into a unifying framework to guide future drug …

Cell Feb 13, 2026

55 Promising

Design 4

Sample 2

Peer Review 19

Replication 16

Transparency 14

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Five genes linked to cellular aging may drive rheumatoid arthritis risk

Using genetic data from large population studies, researchers identified five genes involved in cellular senescence (aging) that appear to causally influence rheumatoid arthritis risk, with BCL2L1 and RAF1 showing the strongest associations. This computational study …

Medicine Feb 12, 2026

46 Early

Design 9

Sample 11

Peer Review 12

Replication 6

Transparency 8

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Boosting Brain Protein Maintenance by Enhancing an Enzyme Linked to Neurodegeneration

This concept paper proposes a new approach to treating Alzheimer's, Parkinson's, and ALS by directly increasing production of OGT—an enzyme that regulates thousands of proteins—rather than using existing indirect methods. The authors suggest using antisense …

Chembiochem : a European journal of chemical biology Feb 12, 2026

30 Early

Design 4

Sample 2

Peer Review 11

Replication 4

Transparency 9

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Why Sertoli Cells Age Faster Than Sperm-Making Cells—And What It Means for Male Fertility

This review reveals that Sertoli cells—the support cells in testes—age faster and suffer more genetic disruption than the germ cells they nurture, accumulating damage from oxidative stress, mitochondrial dysfunction, and epigenetic changes. Understanding how these …

Biogerontology Feb 12, 2026

32 Early

Design 4

Sample 2

Peer Review 15

Replication 8

Transparency 3

How we score →

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Common Molecular Signature of Muscle Wasting Across Cancer, Steroids, and Aging

Researchers discovered that while different causes of muscle wasting (cancer, steroid use, and aging) trigger mostly distinct molecular changes, they all share one common signature: reduced chemical modification of a protein called Lrpprc. Restoring this …

Journal of cachexia, sarcopenia and muscle Feb 12, 2026

47 Early

Design 6

Sample 12

Peer Review 14

Replication 6

Transparency 9

How we score →

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary PubMed

Understanding FOXO proteins: Key to unlocking longevity mechanisms

This review examines FOXO transcription factors—evolutionary conserved proteins linked to lifespan extension in animals and associated with human longevity via genetic studies. The authors argue that FOXO's role in cellular resilience against stress explains its …

The Biochemical journal Feb 12, 2026

33 Early

Design 4

Sample 2

Peer Review 13

Replication 11

Transparency 3

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Can tongue strength predict healthy aging in older adults?

This paper proposes that tongue pressure—how forcefully someone can press their tongue against the roof of their mouth—may be a useful marker of overall frailty and longevity in older people. The authors argue measuring tongue …

Geriatrics & gerontology international Feb 12, 2026

30 Early

Design 4

Sample 2

Peer Review 11

Replication 4

Transparency 9

How we score →