Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Beta-2-Microglobulin and Neurogenesis: What's My Data?

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains.

Mike Lustgarten analyzes beta-2-microglobulin (B2M), a biomarker included in the Grimage epigenetic clock, exploring its role as a pro-aging factor that impairs neurogenesis in mice and is elevated in Alzheimer's disease brains. He presents his …

Mike Lustgarten Feb 15, 2026
51 Promising
Design 11
Sample 9
Peer Review 11
Replication 8
Transparency 12
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Oral Microbiome's Link to Alzheimer's Disease: New Research

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise.

Researchers from Lincoln Memorial University present evidence that oral microbiome imbalance (dysbiosis) may contribute to Alzheimer's disease through a pathway involving periodontal inflammation, cytokine release, and blood-brain barrier compromise. The oral cavity, being closer to …

Mike Lustgarten Feb 15, 2026
43 Early
Design 11
Sample 6
Peer Review 11
Replication 7
Transparency 8
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

Horvath's Epigenetic Clocks: Measuring and Reversing Aging

Steve Horvath pioneered DNA methylation-based biological age clocks that quantify aging at the cellular level, with GrimAge being his most advanced mortality predictor. His work represents a major breakthrough in aging measurement and has attracted …

r/longevity Feb 15, 2026
30 Early
Design 6
Sample 5
Peer Review 7
Replication 7
Transparency 5
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

DMTF1 Gene May Reverse Brain Aging in Neural Stem Cells

Researchers identified DMTF1, a transcription factor, as potentially therapeutic for reversing age-related decline in neural stem cell proliferation caused by telomere shortening. The mechanism involves DMTF1 regulating SWI/SNF chromatin complexes to activate E2F genes, a …

r/longevity Feb 15, 2026
36 Early
Design 12
Sample 6
Peer Review 5
Replication 7
Transparency 6
How we score →
Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Life Expectancy Gains Are Slowing—Here's Why

A PNAS study shows that life expectancy improvements in high-income countries have decelerated 37-52% for cohorts born 1939-2000, primarily because infant mortality is now near zero, eliminating the easy statistical gains of the 20th century. …

r/longevity Feb 15, 2026
34 Early
Design 8
Sample 6
Peer Review 7
Replication 7
Transparency 6
How we score →
Disputed Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Review / Commentary Reddit

Genetics May Account for 50% of Lifespan, New Study Suggests

A 2026 study by Shenhar and Alon claims genetics determine 50–55% of human lifespan—roughly double previous estimates of 15–30%—by filtering out accidental deaths from twin data. The finding suggests aging is a genetically regulated process …

r/Biohackers Feb 15, 2026
16 Weak
Design 3
Sample 2
Peer Review 3
Replication 4
Transparency 4
How we score →
Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

1,500 Days Sober: Biomarkers Show Dramatic Health Recovery After Alcoholism

A 34-year-old documents remarkable biomarker improvements (biological age 23.

A 34-year-old documents remarkable biomarker improvements (biological age 23.7, normalized liver function, excellent metabolic markers) after 1,500 days of sobriety combined with consistent lifestyle practices. The author emphasizes that fundamentals like alcohol elimination, cardio, sleep, …

r/Biohackers Feb 15, 2026
28 Early
Design 3
Sample 2
Peer Review 4
Replication 5
Transparency 14
How we score →
Promising Biomarkers — Aging clocks and measurement tools Review / Commentary Reddit

What Blood Biomarkers Predict Living to 100? Insights from Swedish Centenarian Study

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme markers.

A 35-year Swedish cohort study identified blood biomarker patterns in middle age that distinguish people who lived to 100 from those who didn't, including higher cholesterol and iron but lower glucose, creatinine, and liver enzyme …

r/ScientificNutrition Feb 15, 2026
60 Promising
Design 14
Sample 13
Peer Review 12
Replication 11
Transparency 10
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary Reddit

High-Dose Creatine for Brain Function: 2024 Study Breakdown and Dosing Insights

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.

A Reddit user summarizes recent research suggesting single high-dose creatine (~20g) may improve cognitive processing by 24.5% during sleep deprivation, with vegetarians showing 2x greater benefits than meat-eaters. The post argues current 5g/day recommendations are …

r/Nootropics Feb 15, 2026
37 Early
Design 8
Sample 5
Peer Review 8
Replication 7
Transparency 9
How we score →
Disputed AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other bioRxiv

How Your Brain Uses Predictions to Shape What You See

This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …

biorxiv (preprint) Feb 13, 2026
24 Weak
Design 4
Sample 2
Peer Review 3
Replication 6
Transparency 9
How we score →
Disputed Cellular — Research on cellular-level aging mechanisms In Vitro bioRxiv

How SARS-CoV-2 Shuts Down Host Cells' Protein-Making Machinery

Researchers found that SARS-CoV-2 infection disables a cellular growth regulator called mTORC1, which causes host cells to stop making most of their own proteins while still allowing viral proteins to be produced. This mechanism was …

biorxiv (preprint) Feb 13, 2026
22 Weak
Design 5
Sample 4
Peer Review 3
Replication 5
Transparency 5
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Rewinding the Brain's Age: Gene Therapy Restores Memory in Aging Mice

Researchers used a gene therapy technique to partially "reprogram" neurons that store memories in aged mice and Alzheimer's disease models, reversing signs of aging in those cells and restoring learning and memory to young-animal levels. …

Neuron Feb 13, 2026
45 Early
Design 6
Sample 8
Peer Review 16
Replication 5
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Hedgehog Signaling Might Combat Aging Across Multiple Organs

This review synthesizes evidence that activating Hedgehog signaling—a developmental pathway—may counteract hallmarks of aging like stem cell exhaustion and chronic inflammation across brain, liver, heart, and other tissues. While preclinical results are promising, the authors …

Experimental & molecular medicine Feb 13, 2026
35 Early
Design 4
Sample 2
Peer Review 13
Replication 6
Transparency 10
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

Four blood proteins linked to longevity and healthy aging across generations

Researchers identified four plasma proteins—GSN, F2, CRTAC1, and HP—that predict who will stay healthy and live longer, by analyzing blood samples from elderly Dutch siblings and their middle-aged children over up to 22 years. These …

medrxiv (preprint) Feb 13, 2026
40 Early
Design 11
Sample 13
Peer Review 3
Replication 5
Transparency 8
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Cohort Study medRxiv

Blood Protein Signatures of Cell Aging Predict Health and Disease Risk

Researchers identified protein signatures in blood that reflect aging in 14 different cell types, and found these markers predict disease onset and health status better than general aging markers. In two large longitudinal studies, immune …

medrxiv (preprint) Feb 13, 2026
39 Early
Design 11
Sample 13
Peer Review 3
Replication 5
Transparency 7
How we score →