Promising Cellular — Research on cellular-level aging mechanisms Review / Commentary Reddit

r/longevity Introductory Guide: Resources for Aging Biology Research

This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university labs studying the biology of aging. This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university la

This is a curated introductory post for r/longevity that distinguishes legitimate aging biology research from quackery, providing structured access to academic papers, presentations, and university labs studying the biology of aging. The post establishes the …

r/longevity Feb 15, 2026

64 Promising

Design 13

Sample 12

Peer Review 14

Replication 13

Transparency 12

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Seed Oils vs. Lard: What the Science Actually Shows

Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as 'healthy' is misleading. Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that

Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as …

Peter Attia Feb 15, 2026

55 Promising

Design 13

Sample 8

Peer Review 9

Replication 11

Transparency 14

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Seed Oils and Longevity: Evidence-Based Analysis of Nutritional Harm Claims

Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against seed oils while Norton defends the evidence suggesting they are not uniquely harmful. Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against se

Peter Attia and Lane Norton examine whether seed oils pose unique health risks compared to other dietary fats, using a structured 'steelman' approach where Attia presents the strongest case against seed oils while Norton defends …

Peter Attia Feb 15, 2026

44 Early

Design 13

Sample 0

Peer Review 8

Replication 9

Transparency 14

How we score →

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Exercise, Heat, and Cold: Dr. Patrick's Healthspan Optimization Guide

Dr. Dr. Rhonda Patrick presents evidence that vigorous-intensity exercise is the most powerful anti-aging intervention available, reversing 20 years of heart aging in 2 years, with each unit improvement i

Dr. Rhonda Patrick presents evidence that vigorous-intensity exercise is the most powerful anti-aging intervention available, reversing 20 years of heart aging in 2 years, with each unit improvement in VO2 max adding ~45 days to …

FoundMyFitness Feb 15, 2026

60 Promising

Design 13

Sample 11

Peer Review 12

Replication 12

Transparency 12

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Vigorous Exercise May Be 4-10x More Effective Than Moderate Activity

This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing mortality risk. This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing m

This video discusses a new study challenging the long-standing 1:2 ratio guideline (1 minute vigorous = 2 minutes moderate exercise) by suggesting vigorous activity is 4-10x more potent for reducing mortality risk. The hosts argue …

FoundMyFitness Feb 15, 2026

26 Early

Design 7

Sample 4

Peer Review 5

Replication 4

Transparency 6

How we score →

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary YouTube

Castration & Lifespan: What the Science Actually Shows About Testosterone

A new Nature study finds castration extends lifespan ~10% across animal species and historical Korean eunuchs lived 14-19 years longer, but the mechanism likely involves reduced risky behavior and altered growth hormone pathways—not simply low testosterone. A new Nature study finds castration extends lifespan ~10% across animal species and historical Korean eunuchs lived 14-19 years longer, but the mechanism likely involves reduced risky behavior and alt

A new Nature study finds castration extends lifespan ~10% across animal species and historical Korean eunuchs lived 14-19 years longer, but the mechanism likely involves reduced risky behavior and altered growth hormone pathways—not simply low …

Dr Brad Stanfield Feb 15, 2026

66 Promising

Design 14

Sample 13

Peer Review 13

Replication 12

Transparency 14

How we score →

Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary YouTube

NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science

Dr. Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argue

Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …

Dr Brad Stanfield Feb 15, 2026

67 Promising

Design 14

Sample 13

Peer Review 12

Replication 15

Transparency 13

How we score →

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure

Dr. Dr. Irina Conboy, a leading aging researcher at UC Berkeley, critiques the current methodology and biological validity of epigenetic aging clocks, arguing they optimize for statistical prediction rath

Dr. Irina Conboy, a leading aging researcher at UC Berkeley, critiques the current methodology and biological validity of epigenetic aging clocks, arguing they optimize for statistical prediction rather than biological relevance and fail to detect …

Lifespan.io Feb 15, 2026

66 Promising

Design 15

Sample 13

Peer Review 12

Replication 13

Transparency 13

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Visceral Fat Reduction and Lifespan: Mike Lustgarten's 3-Year Self-Tracking

This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low viscera

This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. ~1300g expected for …

Mike Lustgarten Feb 15, 2026

43 Early

Design 10

Sample 5

Peer Review 11

Replication 6

Transparency 11

How we score →

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Beta-Hydroxybutyrate: The Ketone Link to Longevity in Mice

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through gl

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. The video presents mouse model data showing BHB's …

Mike Lustgarten Feb 15, 2026

48 Early

Design 11

Sample 9

Peer Review 8

Replication 9

Transparency 11

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

TMAO: Health Risks, Dietary Sources, and Personalized Tracking

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The presenter analyzes 21 personal biomarker tests to …

Mike Lustgarten Feb 15, 2026

36 Early

Design 8

Sample 6

Peer Review 7

Replication 7

Transparency 8

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Self-Tracked Diet & Biological Age: One Man's 15-Year Younger Result

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specifi

Mike Lustgarten presents his detailed food tracking data (54 foods over 41 days) correlated with blood biomarkers showing a 15-year younger biological age via an epigenetic clock. He describes specific dietary experiments targeting DHEA-sulfate improvement …

Mike Lustgarten Feb 15, 2026

29 Early

Design 5

Sample 4

Peer Review 6

Replication 3

Transparency 11

How we score →

Disputed Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomark

Longevity self-experimenter Mike Lustgarten documents his supplementation protocol targeting NAD+ levels and homocysteine reduction, measuring outcomes via biological age calculators and blood biomarkers. While he achieved a 48 µM NAD+ level (considered 'optimal' by his …

Mike Lustgarten Feb 15, 2026

24 Weak

Design 3

Sample 2

Peer Review 5

Replication 2

Transparency 12

How we score →

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary YouTube

Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rath

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. He demonstrates a self-tracking …

Mike Lustgarten Feb 15, 2026

41 Early

Design 8

Sample 9

Peer Review 7

Replication 7

Transparency 10

How we score →

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary YouTube

NAD+ Biology and Aging: Expert Insights on Boosting NAD Levels

Dr. Dr. Charles Brenner, a leading NAD researcher and discoverer of nicotinamide riboside, discusses why NAD levels matter for aging, exercise recovery, and disease prevention. He clarifies common misconc

Dr. Charles Brenner, a leading NAD researcher and discoverer of nicotinamide riboside, discusses why NAD levels matter for aging, exercise recovery, and disease prevention. He clarifies common misconceptions about NAD decline with age and explains …

FoundMyFitness Feb 15, 2026

64 Promising

Design 14

Sample 11

Peer Review 12

Replication 13

Transparency 14

How we score →