This review examines how CXC chemokines—signaling proteins released by aging cells—contribute to age-related diseases and cancer. The authors propose these molecules could become biomarkers for aging and targets for new longevity therapies, though most evidence …
This review highlights how T cells in the brain show signs of exhaustion as we age, and describes a promising engineered immune protein that could restore brain immune function by rebalancing inflammatory signals. The work …
Researchers discovered that IL-2 signaling in B cells activates a regulatory program that produces anti-inflammatory IL-10, especially in aging B cells. In a mouse model of multiple sclerosis, this pathway was protective—loss of IL-2 signaling …
Researchers mapped five key energy-producing pathways across the human brain using genetic data, finding they're distributed differently in sensory areas and follow distinct aging patterns—peaking in childhood for energy production, but declining throughout life for …
Researchers found that kidney damage from aging and hypertension is associated with accumulation of senescent (aging) cells in the glomeruli—the kidney's filtering units. The study identifies specific molecular markers of cellular senescence that correlate with …
In adults aged 85+, researchers used advanced pattern-matching analysis to find that drops in blood pressure preceded cognitive decline, while rises in blood pressure preceded difficulty with daily activities. This suggests BP changes in very …
This is a protocol paper announcing a planned scoping review that will search the scientific literature for evidence connecting oral microbiome composition to three common aging syndromes: frailty, muscle loss, and cognitive disorders in people …
Researchers developed engineered immune-targeting proteins to reduce brain inflammation and boost neurogenesis in aged mice, resulting in improved cognitive performance. The approach demonstrates that modulating immune dysfunction—a hallmark of aging—may be a viable strategy to …
Researchers bred a predatory bug (Orius albidipennis) to produce 76% more eggs than normal without observing the typical trade-off where high reproduction shortens lifespan or reduces hunting ability. This finding challenges evolutionary theory and could …
Researchers studied how GABA receptors—which normally act as brakes on brain activity—change in mice genetically engineered to develop amyloid pathology similar to Alzheimer's disease. They found that these receptors are altered by the disease itself, …
Transplanting young muscle stem cells into aged mice improved motor function and reduced anxiety through secreted proteins that promote blood vessel growth and immune regulation. The benefits persisted for up to 2 months, suggesting these …
Researchers in Italy are establishing a large longitudinal cohort study to track how people age, combining detailed health assessments with genetic and protein measurements. Early results show the approach works and reveal links between frailty …
Researchers found that aging plants lose epigenetic control—specifically, DNA methylation patterns decay over time, allowing normally silenced genes to turn on. Remarkably, they identified a genetic program that can be manipulated to prevent this decay …
This is a materials science paper about battery electrode design, not longevity research. It describes a method to improve tin anode performance in aqueous batteries by controlling ion nucleation patterns. While innovative for battery technology, …
Researchers fed fruit flies 20 different types of cereal grains and found that female flies lived 3-13% longer while males lived up to 19% shorter, depending on the cereal type. The sex-specific effects appear linked …