A small clinical trial found that extracellular vesicles from a patient's own blood can treat temporomandibular joint osteoarthritis by selectively eliminating senescent (aged) chondrocytes and promoting bone regeneration. The therapy worked better than hyaluronic acid …
Researchers found that WTAP, a protein involved in gene regulation, is overactive in periodontitis and causes stem cells in the tooth-supporting tissue to age prematurely and lose their ability to form bone. Blocking WTAP reversed …
Researchers validated a quick executive function test (TCST) that can reliably distinguish normal aging from Alzheimer's disease with 84% accuracy. The study provides age-adjusted scoring norms that make the test more clinically useful for early …
In a longitudinal study of over 30,000 Canadian adults aged 45–85, those at high risk of obstructive sleep apnea (OSA) had approximately 40% higher odds of depression, anxiety, or other mental health conditions—both at baseline …
This review argues that senescent cells—aging cells stuck in a non-dividing state—can actually promote cancer growth and drug resistance, and that new drugs called senotherapeutics could selectively kill these problematic cells alongside standard cancer treatments. …
A polysaccharide extract from Ganoderma atrum fungus extended lifespan by ~23% in C. elegans and improved markers of healthy aging by activating two key longevity pathways (IIS and MAPK). While the findings are promising for …
Fanconi anaemia, a rare genetic disorder of DNA repair, compresses multiple hallmarks of aging into childhood—offering scientists a natural 'fast-forward' model to study how genome damage, immune dysfunction, and epigenetic changes drive aging and cancer. …
This commentary argues that oxytocin, a hormone that decreases with age, may be a master regulator of aging through epigenetic changes, mitochondrial damage, and inflammation—and that nasal oxytocin administration could reverse these effects. The claims …
This essay identifies critical gaps in our understanding of why males and females show different rates of age-related diseases, infections, and vaccine responses—differences driven by sex hormones and genetics. The authors outline priority research areas …
This review examines follistatin-like protein 1 (FSTL1), a secreted protein that regulates inflammation, cellular aging, and tumor growth through multiple signaling pathways. The authors propose FSTL1 as a promising therapeutic target for age-related diseases like …
Researchers found that liraglutide, a GLP-1 drug used for diabetes, improved mitochondrial function and reduced oxidative stress in aging heart cells made insulin-resistant in the lab. The effect required a protein called casein kinase 2 …
Researchers found that B cells (immune cells) drive the aging of CD4 T cells, a key component of adaptive immunity, and that removing B cells extended both healthspan and lifespan in mice. The effect appears …
Researchers compared three methods for measuring how well older adults bounce back from illness or injury, testing them in two groups: cancer patients undergoing chemotherapy and emergency department patients. They found that the different methods …
Researchers identified 13 genes that are mutated in both amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease (CMT)—two otherwise distinct neurological disorders. This suggests that despite their clinical differences, these diseases may operate through overlapping molecular …
Researchers found that eugenol, a natural compound from cloves, can reduce premature aging in blood vessel cells by suppressing a protein called MFG-E8. The effect was demonstrated in both cell cultures and aged mice, suggesting …