Researchers found that a key fat-absorption protein (FATP4) drops by over 50% in the intestines of aging mice, which correlates with a 4% decline in fat digestibility. This molecular change may explain why older adults …
This study found that older adults show increased 'neural noise' (flatter EEG patterns) compared to younger adults during working memory tasks, and this noise correlates with less efficient brain processing. The findings suggest aging brains …
Researchers found that people with multiple adverse childhood experiences (ACEs) show reduced brain volume in key emotional and cognitive regions well into mid- and late adulthood, and these changes don't fully explain the link between …
This study of 210 older adults found that problematic personality traits are more strongly linked to difficulty *managing* emotions than to how often people *use* specific coping strategies. Different personality problems showed distinct patterns—for example, …
Researchers discovered that muscle stem cells age by boosting a survival gene (NDRG1) that extends their lifespan but cripples their ability to repair muscle after injury. This represents a cellular trade-off: living longer at the …
This review examines circular RNAs (circRNAs)—stable, ring-shaped molecules in cells—and proposes they may be key to how exercise protects muscles from age-related decline. While animal and cell studies show promise, functional evidence in humans remains …
This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …
Researchers found that the health of a small brain region called the locus coeruleus is linked to deep sleep loss in aging and Alzheimer's disease, with stronger effects in women. The study suggests that protecting …
This review examines how chronic, low-grade inflammation (inflammaging) damages muscles, joints, and movement control in older adults, and explores both lifestyle and emerging drug-based approaches to slow mobility decline. While it synthesizes existing knowledge rather …
Researchers discovered that oxygen-starved endometrial cancer cells produce excess lactate, which they feed to immune cells (macrophages) to reprogram them into cancer-promoting phenotypes. This happens via a molecular switch involving DNA methyltransferase and pH regulation, …
Researchers analyzed blood proteins from Swiss centenarians and discovered 37 proteins associated with a 'younger' profile that may explain why some people live to 100 and stay healthy. By comparing centenarian patterns across two independent …
A study of 41 children with Morquio A, a rare genetic disorder affecting bone and organ development, found that allogeneic hematopoietic cell transplantation (essentially replacing diseased blood-forming cells with healthy donor cells) was safe and …
A study of nearly 2,000 older adults found that people with greater cognitive enrichment over their lifetime—like education, mentally stimulating activities, and learning—had a 38% lower risk of developing Alzheimer's dementia and delayed its onset …
Researchers found that moderate to severe periodontitis (gum disease) is associated with higher mortality risk, and this connection appears to work partly through accelerated biological aging—measured by two epigenetic clocks (PhenoAge and KDM). While biological …
This study maps where cannabinoid type-1 receptors are located in the mouse visual cortex and found they're distributed differently in adolescence versus adulthood, particularly among specific types of inhibitory brain cells. The findings suggest the …