Researchers found that kidney damage from aging and hypertension is associated with accumulation of senescent (aging) cells in the glomeruli—the kidney's filtering units. The study identifies specific molecular markers of cellular senescence that correlate with …
In adults aged 85+, researchers used advanced pattern-matching analysis to find that drops in blood pressure preceded cognitive decline, while rises in blood pressure preceded difficulty with daily activities. This suggests BP changes in very …
This is a protocol paper announcing a planned scoping review that will search the scientific literature for evidence connecting oral microbiome composition to three common aging syndromes: frailty, muscle loss, and cognitive disorders in people …
Researchers developed engineered immune-targeting proteins to reduce brain inflammation and boost neurogenesis in aged mice, resulting in improved cognitive performance. The approach demonstrates that modulating immune dysfunction—a hallmark of aging—may be a viable strategy to …
Researchers bred a predatory bug (Orius albidipennis) to produce 76% more eggs than normal without observing the typical trade-off where high reproduction shortens lifespan or reduces hunting ability. This finding challenges evolutionary theory and could …
Researchers studied how GABA receptors—which normally act as brakes on brain activity—change in mice genetically engineered to develop amyloid pathology similar to Alzheimer's disease. They found that these receptors are altered by the disease itself, …
Transplanting young muscle stem cells into aged mice improved motor function and reduced anxiety through secreted proteins that promote blood vessel growth and immune regulation. The benefits persisted for up to 2 months, suggesting these …
Researchers in Italy are establishing a large longitudinal cohort study to track how people age, combining detailed health assessments with genetic and protein measurements. Early results show the approach works and reveal links between frailty …
Researchers found that aging plants lose epigenetic control—specifically, DNA methylation patterns decay over time, allowing normally silenced genes to turn on. Remarkably, they identified a genetic program that can be manipulated to prevent this decay …
This is a materials science paper about battery electrode design, not longevity research. It describes a method to improve tin anode performance in aqueous batteries by controlling ion nucleation patterns. While innovative for battery technology, …
Researchers fed fruit flies 20 different types of cereal grains and found that female flies lived 3-13% longer while males lived up to 19% shorter, depending on the cereal type. The sex-specific effects appear linked …
A small clinical trial found that extracellular vesicles from a patient's own blood can treat temporomandibular joint osteoarthritis by selectively eliminating senescent (aged) chondrocytes and promoting bone regeneration. The therapy worked better than hyaluronic acid …
Researchers found that WTAP, a protein involved in gene regulation, is overactive in periodontitis and causes stem cells in the tooth-supporting tissue to age prematurely and lose their ability to form bone. Blocking WTAP reversed …
Researchers validated a quick executive function test (TCST) that can reliably distinguish normal aging from Alzheimer's disease with 84% accuracy. The study provides age-adjusted scoring norms that make the test more clinically useful for early …
In a longitudinal study of over 30,000 Canadian adults aged 45–85, those at high risk of obstructive sleep apnea (OSA) had approximately 40% higher odds of depression, anxiety, or other mental health conditions—both at baseline …