This review argues that senescent cells—aging cells stuck in a non-dividing state—can actually promote cancer growth and drug resistance, and that new drugs called senotherapeutics could selectively kill these problematic cells alongside standard cancer treatments. …
A polysaccharide extract from Ganoderma atrum fungus extended lifespan by ~23% in C. elegans and improved markers of healthy aging by activating two key longevity pathways (IIS and MAPK). While the findings are promising for …
Fanconi anaemia, a rare genetic disorder of DNA repair, compresses multiple hallmarks of aging into childhood—offering scientists a natural 'fast-forward' model to study how genome damage, immune dysfunction, and epigenetic changes drive aging and cancer. …
This commentary argues that oxytocin, a hormone that decreases with age, may be a master regulator of aging through epigenetic changes, mitochondrial damage, and inflammation—and that nasal oxytocin administration could reverse these effects. The claims …
This essay identifies critical gaps in our understanding of why males and females show different rates of age-related diseases, infections, and vaccine responses—differences driven by sex hormones and genetics. The authors outline priority research areas …
This review examines follistatin-like protein 1 (FSTL1), a secreted protein that regulates inflammation, cellular aging, and tumor growth through multiple signaling pathways. The authors propose FSTL1 as a promising therapeutic target for age-related diseases like …
Researchers found that liraglutide, a GLP-1 drug used for diabetes, improved mitochondrial function and reduced oxidative stress in aging heart cells made insulin-resistant in the lab. The effect required a protein called casein kinase 2 …
Researchers found that B cells (immune cells) drive the aging of CD4 T cells, a key component of adaptive immunity, and that removing B cells extended both healthspan and lifespan in mice. The effect appears …
Researchers compared three methods for measuring how well older adults bounce back from illness or injury, testing them in two groups: cancer patients undergoing chemotherapy and emergency department patients. They found that the different methods …
Researchers identified 13 genes that are mutated in both amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease (CMT)—two otherwise distinct neurological disorders. This suggests that despite their clinical differences, these diseases may operate through overlapping molecular …
Researchers found that eugenol, a natural compound from cloves, can reduce premature aging in blood vessel cells by suppressing a protein called MFG-E8. The effect was demonstrated in both cell cultures and aged mice, suggesting …
Researchers found that a key fat-absorption protein (FATP4) drops by over 50% in the intestines of aging mice, which correlates with a 4% decline in fat digestibility. This molecular change may explain why older adults …
This study found that older adults show increased 'neural noise' (flatter EEG patterns) compared to younger adults during working memory tasks, and this noise correlates with less efficient brain processing. The findings suggest aging brains …
Researchers found that people with multiple adverse childhood experiences (ACEs) show reduced brain volume in key emotional and cognitive regions well into mid- and late adulthood, and these changes don't fully explain the link between …
This study of 210 older adults found that problematic personality traits are more strongly linked to difficulty *managing* emotions than to how often people *use* specific coping strategies. Different personality problems showed distinct patterns—for example, …