A 60-day online gaming community with professional facilitation reduced depression and anxiety symptoms by moderate amounts in adults who play video games, with about 21% of participants moving from moderate-to-severe depression into healthier ranges. While …
This review examines Akkermansia muciniphila, a beneficial gut bacterium that declines with age and is linked to inflammation and metabolic problems. While some studies show it strengthens the intestinal barrier and reduces aging-related decline, others …
Researchers discovered that a protein called LHX1 silences STING, a cellular alarm system that triggers senescence (aging) and tumor suppression in head and neck cancer cells. Disrupting LHX1 reactivates this alarm, causing cancer cells to …
Researchers found that glycine supplementation extended lifespan in fruit flies and improved age-related damage in rats by activating a protein called Nmdmc that enhances mitochondrial energy production and DNA repair. The mechanism involves reshaping how …
Researchers used imaging in 285 macaques and postmortem human eyes to map how the retina thickens during development but thins with age—a pattern that could help us understand age-related vision loss. The findings suggest macaques …
This narrative review examines whether three readily available blood markers—lymphopenia, neutrophilia, and the neutrophil-to-lymphocyte ratio (NLR)—can reliably indicate immune aging and predict severe COVID-19 outcomes in elderly patients. The authors conclude these markers consistently correlate …
This paper argues that 'identification'—feeling a sense of sameness with another person—is a fundamental mental process rooted in both psychology and brain biology, especially important when we're under stress or trauma. The authors propose that …
Researchers found that a protein called TIMP2 is overproduced after acute kidney injury and actively drives the transition to chronic kidney disease by promoting cell aging and scarring. Deleting TIMP2 in kidney tubule cells in …
Researchers found that people diagnosed with schizophrenia age faster on a biological level than the general population, using a novel brain imaging measure of aging. This finding, replicated across four independent datasets, could explain why …
Researchers identified eight genes linked to cellular senescence that can predict which liver cancer patients will survive longer and respond to immunotherapy. The findings come from analyzing gene expression patterns in individual cancer cells and …
This study identifies why immune cells (NK cells) from older adults become ineffective at removing senescent fibroblasts—harmful aging cells that accumulate in tissues. The culprit is overactivity of a protein called Cdc42, which disrupts the …
This editorial discusses a new study finding that higher glutathione (an antioxidant) levels in the brain correlate with better cognitive performance in older adults, measured using brain imaging. However, the authors note that findings across …
This large national study found that exposure to common air pollutants—especially fine particulate matter (PM2.5)—increases the risk that older adults will develop mobility problems and makes it harder for them to bounce back to full …
Researchers developed MuPPE, a streamlined platform that analyzes three types of protein modifications (glycosylation, phosphorylation, and overall protein levels) from a single tissue sample in 4 hours instead of 32 hours. When applied to aging …
Researchers used a rat model combining radiation and a sugar that accelerates aging to test naringin, a natural compound from citrus fruits. Naringin reduced markers of brain aging, inflammation, and cell death in treated animals, …