Researchers discovered that muscle stem cells age by boosting a survival gene (NDRG1) that extends their lifespan but cripples their ability to repair muscle after injury. This represents a cellular trade-off: living longer at the …
This review examines circular RNAs (circRNAs)—stable, ring-shaped molecules in cells—and proposes they may be key to how exercise protects muscles from age-related decline. While animal and cell studies show promise, functional evidence in humans remains …
This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …
Researchers found that the health of a small brain region called the locus coeruleus is linked to deep sleep loss in aging and Alzheimer's disease, with stronger effects in women. The study suggests that protecting …
This review examines how chronic, low-grade inflammation (inflammaging) damages muscles, joints, and movement control in older adults, and explores both lifestyle and emerging drug-based approaches to slow mobility decline. While it synthesizes existing knowledge rather …
Researchers discovered that oxygen-starved endometrial cancer cells produce excess lactate, which they feed to immune cells (macrophages) to reprogram them into cancer-promoting phenotypes. This happens via a molecular switch involving DNA methyltransferase and pH regulation, …
Researchers analyzed blood proteins from Swiss centenarians and discovered 37 proteins associated with a 'younger' profile that may explain why some people live to 100 and stay healthy. By comparing centenarian patterns across two independent …
A study of 41 children with Morquio A, a rare genetic disorder affecting bone and organ development, found that allogeneic hematopoietic cell transplantation (essentially replacing diseased blood-forming cells with healthy donor cells) was safe and …
Researchers discovered that telomerase doesn't just work on the finished ends of chromosomes—it also repairs breaks that happen *during* DNA replication at chromosome tips, and does so much more frequently than previously thought. This challenges …
This study reveals how a fungus (Neurospora crassa) uses two cellular signaling pathways to coordinate cell fusion—one pathway activates the machinery for building cellular structures, while the other aims that machinery at the right location. …
A study of nearly 2,000 older adults found that people with greater cognitive enrichment over their lifetime—like education, mentally stimulating activities, and learning—had a 38% lower risk of developing Alzheimer's dementia and delayed its onset …
Researchers found that moderate to severe periodontitis (gum disease) is associated with higher mortality risk, and this connection appears to work partly through accelerated biological aging—measured by two epigenetic clocks (PhenoAge and KDM). While biological …
This study maps where cannabinoid type-1 receptors are located in the mouse visual cortex and found they're distributed differently in adolescence versus adulthood, particularly among specific types of inhibitory brain cells. The findings suggest the …
Researchers developed FastGxC, a computational method that finds genes whose activity changes depending on tissue or cell type context—a key mechanism in disease risk. The tool is a million times faster than existing approaches and …
A 60-day online gaming community with professional facilitation reduced depression and anxiety symptoms by moderate amounts in adults who play video games, with about 21% of participants moving from moderate-to-severe depression into healthier ranges. While …